PTGDR2, prostaglandin D2 receptor 2, 11251

N. diseases: 60; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3662483
Disease: Allergic sensitization
Allergic sensitization 		0.010 GeneticVariation disease BEFREE Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children. 19392992 2009
CUI: C0017152
Disease: Gastritis
Gastritis 		0.010 Biomarker disease BEFREE Recently, prostaglandin D2 was shown to be involved in host immunity by chemotactic activity through chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), but its role in H. pylori-induced gastritis has not been clarified. 19768745 2009
CUI: C0004096
Disease: Asthma
Asthma 		0.400 AlteredExpression disease BEFREE Considering the fact that eosinophil infiltration is prominent in the upper and lower airways of aspirin exacerbated respiratory disease (AERD) compared to aspirin-tolerant asthma (ATA) patients, we hypothesized that activation of eosinophils via dysregulation of the CRTH2 gene may play an important role and be an important marker for AERD. 19796209 2010
CUI: C3853540
Disease: Aspirin exacerbated respiratory disease
Aspirin exacerbated respiratory disease 		0.020 GeneticVariation disease BEFREE A significant difference in the genotype frequencies of CRTH2 -466T>C was detected between AERD and ATA patients (P < 0.05). 19796209 2010
CUI: C0004135
Disease: Ataxia Telangiectasia
Ataxia Telangiectasia 		0.010 GeneticVariation disease BEFREE A significant difference in the genotype frequencies of CRTH2 -466T>C was detected between AERD and ATA patients (P < 0.05). 19796209 2010
CUI: C1319853
Disease: Asthma, Aspirin-Induced
Asthma, Aspirin-Induced 		0.300 Biomarker disease CTD_human Genetic and ethnic risk factors associated with drug hypersensitivity. 20485159 2010
CUI: C3853540
Disease: Aspirin exacerbated respiratory disease
Aspirin exacerbated respiratory disease 		0.020 GeneticVariation disease BEFREE Thromboxane A2 receptor +795T>C and chemoattractant receptor-homologous molecule expressed on Th2 cells -466T>C gene polymorphisms in patients with aspirin-exacerbated respiratory disease. 22101342 2012
CUI: C0004096
Disease: Asthma
Asthma 		0.400 Biomarker disease BEFREE Herein we present evidence that PGH(1) is a potent activator of the pro-inflammatory PGD(2) receptor CRTH2, an attractive therapeutic target to treat allergic diseases such as asthma and atopic dermatitis. 22442685 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.030 Biomarker disease BEFREE Herein we present evidence that PGH(1) is a potent activator of the pro-inflammatory PGD(2) receptor CRTH2, an attractive therapeutic target to treat allergic diseases such as asthma and atopic dermatitis. 22442685 2012
CUI: C0013595
Disease: Eczema
Eczema 		0.020 Biomarker disease BEFREE Herein we present evidence that PGH(1) is a potent activator of the pro-inflammatory PGD(2) receptor CRTH2, an attractive therapeutic target to treat allergic diseases such as asthma and atopic dermatitis. 22442685 2012
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.040 GeneticVariation disease BEFREE Here, we assessed the association between CRTh2 rs533116 and allergic asthma, expression of CRTh2 and Th2 cytokine production. 22947041 2012
CUI: C0699949
Disease: airway disease
airway disease 		0.010 GeneticVariation disease BEFREE CRTh2 rs533116 was associated with allergic asthma in White people (2.67 [1.09-6.55], P < 0.05), and expression of CRTh2 was higher in subjects with allergic airways disease compared to controls (P < 0.05). 22947041 2012
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.010 AlteredExpression disease BEFREE Taken together, these data suggest that blocking the activation of CRTH2 by PGD(2) might be a strategy to slow the progression of renal fibrosis in CKD. 22997255 2012
CUI: C1969372
Disease: Tubulointerstitial fibrosis
Tubulointerstitial fibrosis 		0.010 Biomarker phenotype BEFREE PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis. 22997255 2012
CUI: C0149516
Disease: Chronic sinusitis
Chronic sinusitis 		0.020 Biomarker disease BEFREE CRTH2(+) ILC2s were enriched in nasal polyps of patients with chronic rhinosinusitis, a typical type 2-mediated disease. 23063330 2012
CUI: C0004096
Disease: Asthma
Asthma 		0.400 AlteredExpression disease BEFREE Asthma exacerbations, poor asthma control, and TH2 inflammatory markers were associated with higher PGD₂, HPGDS, and CRTH2 levels. 23506843 2013
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.010 Biomarker disease BEFREE Our results show that i) aPC induced the secretion of several cytokines in Ovcar-3 cells; ii) 61% of patients exhibited a concentration of plasma sEPCR well above the baseline (normal plasma level, 100 ± 28 ng/ml); iii) comparing immune cell phenotypes in patients having a normal level of sEPCR with those having a high level of sEPCR, it was found that sEPCR levels were correlated with high intensity of cells expressing CD45ra, CD3, CD8, CD25 and low intensity of cells expressing CD56 (NK cells), CD294 (TH2 cells), IL-2, IL-10, IL-17a (TH17 cells), IL-21 (TH21 cells) and CD29 markers (r ≥ 0.60); and iv) high levels of sEPCR correlate with high levels of plasma bioactive proteins such as insulin-like growth factor-2 (IGFII), IL-13rα, macrophage inflammatory protein (MIP1α) and matrix metalloproteinase-7 (MMP-7) that have already been proposed as biomarkers for ovarian cancer and particularly those with poor prognosis. 23877403 2013
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.010 Biomarker disease BEFREE Our results show that i) aPC induced the secretion of several cytokines in Ovcar-3 cells; ii) 61% of patients exhibited a concentration of plasma sEPCR well above the baseline (normal plasma level, 100 ± 28 ng/ml); iii) comparing immune cell phenotypes in patients having a normal level of sEPCR with those having a high level of sEPCR, it was found that sEPCR levels were correlated with high intensity of cells expressing CD45ra, CD3, CD8, CD25 and low intensity of cells expressing CD56 (NK cells), CD294 (TH2 cells), IL-2, IL-10, IL-17a (TH17 cells), IL-21 (TH21 cells) and CD29 markers (r ≥ 0.60); and iv) high levels of sEPCR correlate with high levels of plasma bioactive proteins such as insulin-like growth factor-2 (IGFII), IL-13rα, macrophage inflammatory protein (MIP1α) and matrix metalloproteinase-7 (MMP-7) that have already been proposed as biomarkers for ovarian cancer and particularly those with poor prognosis. 23877403 2013
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.010 Biomarker disease BEFREE Our results show that i) aPC induced the secretion of several cytokines in Ovcar-3 cells; ii) 61% of patients exhibited a concentration of plasma sEPCR well above the baseline (normal plasma level, 100 ± 28 ng/ml); iii) comparing immune cell phenotypes in patients having a normal level of sEPCR with those having a high level of sEPCR, it was found that sEPCR levels were correlated with high intensity of cells expressing CD45ra, CD3, CD8, CD25 and low intensity of cells expressing CD56 (NK cells), CD294 (TH2 cells), IL-2, IL-10, IL-17a (TH17 cells), IL-21 (TH21 cells) and CD29 markers (r ≥ 0.60); and iv) high levels of sEPCR correlate with high levels of plasma bioactive proteins such as insulin-like growth factor-2 (IGFII), IL-13rα, macrophage inflammatory protein (MIP1α) and matrix metalloproteinase-7 (MMP-7) that have already been proposed as biomarkers for ovarian cancer and particularly those with poor prognosis. 23877403 2013
CUI: C0008728
Disease: Eosinophilic granulomatosis with polyangiitis
Eosinophilic granulomatosis with polyangiitis 		0.010 AlteredExpression disease BEFREE The CD4+ lymphocytes of EGPA patients revealed a higher expression of CRTH2 and increased production of IL-5. 24632064 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.400 Biomarker disease BEFREE The D prostanoid receptor 2 (DP2; also known as chemoattractant receptor-homologous molecule expressed on TH2 cells) is implicated in the pathogenesis of asthma, but its expression within bronchial biopsy specimens is unknown. 25312757 2015
CUI: C0242994
Disease: Hantavirus Infections
Hantavirus Infections 		0.010 Biomarker group BEFREE In contrast, the fibrosis was due to interactions between CHI3L1 and the receptor CRTH2, which trafficked normally in BLOC-3 mutant HPS. 26121745 2015
CUI: C0004096
Disease: Asthma
Asthma 		0.400 Biomarker disease BEFREE Current treatment options for severe asthma are inadequate and therapeutic antibody-mediated depletion of CRTh2-expressing cells represents a promising new therapeutic strategy. 27103662 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.400 Therapeutic disease CTD_human Current treatment options for severe asthma are inadequate and therapeutic antibody-mediated depletion of CRTh2-expressing cells represents a promising new therapeutic strategy. 27103662 2016
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.040 Biomarker disease BEFREE AZD1981 is an orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) receptor antagonist progressed to phase II trials for the treatment of allergic asthma. 27558866 2017