PTGDR2, prostaglandin D2 receptor 2, 11251

N. diseases: 60; N. variants: 1
Disease: Allergic rhinitis (disorder) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.030 Biomarker disease BEFREE PGD<sub>2</sub> -CRTH2 and cysLTs-CysLT1 axes may activate tissue-resident ILC2s to produce Th2 cytokines, IL-5 and IL-13, leading to the development of allergic inflammation in AR. 31267527 2019
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.030 Biomarker disease BEFREE These results open channels for therapeutic modalities targeting CRTH2 molecules in AR. 28222358 2017
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.030 Biomarker disease BEFREE The clear discrepancy between animal studies and clinical efficacy of CRTH2 antagonism in allergic rhinitis, and lack of efficacy in a general cohort of asthmatics, highlight the issue of patient phenotyping. 28612233 2017