HRH3, histamine receptor H3, 11255

N. diseases: 60; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002622
Disease: Amnesia
Amnesia
0.510 Biomarker disease BEFREE Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats. 30863075 2019
CUI: C0002622
Disease: Amnesia
Amnesia
0.510 Biomarker disease RGD Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats. 17276409 2007
CUI: C0002622
Disease: Amnesia
Amnesia
0.510 Biomarker disease CTD_human Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. 11125734 1999
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.500 Biomarker group CTD_human Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. 9050021 1997
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.500 Biomarker group RGD Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. 9050021 1997
CUI: C0233794
Disease: Memory impairment
Memory impairment
0.320 Biomarker phenotype BEFREE Histamine H3 Receptor Antagonist Prevents Memory Deficits and Synaptic Plasticity Disruption Following Isoflurane Exposure. 28168839 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment
0.320 Biomarker phenotype BEFREE The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats. 29075190 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment
0.320 Biomarker phenotype CTD_human Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats. 16488453 2006
CUI: C0025261
Disease: Memory Disorders
Memory Disorders
0.300 Biomarker disease CTD_human Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats. 16488453 2006
CUI: C0751292
Disease: Age-Related Memory Disorders
Age-Related Memory Disorders
0.300 Biomarker group CTD_human Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats. 16488453 2006
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic
0.300 Biomarker phenotype CTD_human Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats. 16488453 2006
CUI: C0751294
Disease: Memory Disorder, Spatial
Memory Disorder, Spatial
0.300 Biomarker phenotype CTD_human Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats. 16488453 2006
CUI: C0751295
Disease: Memory Loss
Memory Loss
0.300 Biomarker phenotype CTD_human Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats. 16488453 2006
CUI: C0233750
Disease: Hysterical amnesia
Hysterical amnesia
0.300 Biomarker phenotype CTD_human Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. 11125734 1999
CUI: C0233796
Disease: Temporary Amnesia
Temporary Amnesia
0.300 Biomarker phenotype CTD_human Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. 11125734 1999
CUI: C0236795
Disease: Dissociative Amnesia
Dissociative Amnesia
0.300 Biomarker phenotype CTD_human Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. 11125734 1999
CUI: C0262497
Disease: Global Amnesia
Global Amnesia
0.300 Biomarker phenotype CTD_human Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. 11125734 1999
CUI: C0750906
Disease: Tactile Amnesia
Tactile Amnesia
0.300 Biomarker phenotype CTD_human Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. 11125734 1999
CUI: C0750907
Disease: Amnestic State
Amnestic State
0.300 Biomarker phenotype CTD_human Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. 11125734 1999
CUI: C0028754
Disease: Obesity
Obesity
0.230 Biomarker disease BEFREE Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II). 23591112 2013
CUI: C0028754
Disease: Obesity
Obesity
0.230 Biomarker disease BEFREE Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I). 23591110 2013
CUI: C0028754
Disease: Obesity
Obesity
0.230 Biomarker disease RGD The present study suggests that antagonistic targeting of the histamine H(3) receptor decreases food intake, body weight, and plasma TG levels and, thus, represents an interesting approach to treatment of obesity and associated hyperlipidemia. 17189541 2006
CUI: C0028754
Disease: Obesity
Obesity
0.230 Biomarker disease BEFREE Histamine H(3) receptor antagonists are potential therapeutic agents for cognitive dysfunction, epilepsy, hypersomnia and obesity. 16316645 2006
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.210 Biomarker disease BEFREE The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats. 31739417 2019
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.210 Biomarker disease RGD Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures. 16137576 2005