IL17F, interleukin 17F, 112744

N. diseases: 236; N. variants: 10
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.020 Biomarker disease BEFREE Increased synthesis of IL-17B, IL-17E and IL-17F appears to play a role in the pathogenesis of SSc, in contrast to IL-17A. 31110538 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.020 AlteredExpression disease BEFREE Moreover, IL-17A, not IL-17F, reduced the protein expression of α1(I) collagen and connective tissue growth factor. miR-129-5p, one of the downregulated microRNAs in SSc fibroblasts, increased due to IL-17A and mediated the α1(I) collagen reduction. 22403442 2012