KLHL2, kelch like family member 2, 11275

N. diseases: 18; N. variants: 1
Disease: Encephalitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014038
Disease: Encephalitis
Encephalitis 		0.020 Biomarker disease BEFREE The findings highlight the complex nature of encephalitis and suggests that IL-1 has a protective effect for the development of MAV-1-induced encephalitis. 27903802 2017
CUI: C0014038
Disease: Encephalitis
Encephalitis 		0.020 AlteredExpression disease BEFREE These results indicate that increased MMP activity in the brains of MAV-1-infected susceptible mice may be due to MMP activity produced by endothelial cells, astrocytes, and microglia, which in turn may contribute to BBB disruption and encephalitis in susceptible mice.<b>IMPORTANCE</b> RNA and DNA viruses can cause encephalitis; in some cases, this is accompanied by MMP-mediated disruption of the BBB. 28053109 2017