TREX1, three prime repair exonuclease 1, 11277

N. diseases: 241; N. variants: 36
Disease: Inflammatory disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1290884
Disease: Inflammatory disorder
Inflammatory disorder 		0.040 GeneticVariation group BEFREE Aicardi-Goutières syndrome is an inflammatory disease occurring due to mutations in any of TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR or IFIH1. 25604658 2015
CUI: C1290884
Disease: Inflammatory disorder
Inflammatory disorder 		0.040 Biomarker group BEFREE Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. 25848017 2015
CUI: C1290884
Disease: Inflammatory disorder
Inflammatory disorder 		0.040 GeneticVariation group BEFREE Mutations in Trex1 gene are being linked to the development of Aicardi-Goutières syndrome, an inflammatory disease of the brain, and systemic lupus erythematosus. 24218451 2013
CUI: C1290884
Disease: Inflammatory disorder
Inflammatory disorder 		0.040 Biomarker group BEFREE Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. 19442247 2009