|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Higher KLF8 expression associated with larger tumour size (P < 0.001), advanced T stage (P = 0.003) and N stage (P < 0.001).
|
31124603 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, highly expression of KLF8 was also closely associated with metastasis (HR = 1.37, 95% CI: 0.57-2.17) and tumor node metastasis stage (HR = 1.58, 95% CI: 0.90-2.25) in carcinomas.
|
31045845 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry, quantitative RT-PCR, western blotting, promoter reporter assays, chromatin immunoprecipitation (ChIP), and chicken chorioallantoic membrane (CAM) and nude mouse tumor models were used to show that the mRNA and protein expression levels of KLF8 and VEGFA are highly correlated in HCC tissue samples.
|
30479372 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that KLF8 was highly expressed in primary HCC tumors, distant migrated tissues, and LCSCs.
|
27478926 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, KLF8 may affect invasion and metastasis of tumors.
|
28810596 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLF8 knockdown suppressed PC tumor growth in nude mice model.
|
26995652 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A xenograft model was used to study the effect of KLF8 on tumor growth and sensitivity to TMZ.
|
27081861 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the molecular mechanism by which KLF8 affects FHL2-mediated tumor proliferation, EMT and metastasis remains unknown.
|
26320172 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although overexpression of KLF8 has been observed in a variety of human tumor types, the role of KLF8 in human osteosarcoma is yet to be elucidated.
|
24604387 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this work, we first correlated KLF8 overexpression with the aggressiveness of ovarian patient tumors and then tested if KLF8 could transform human ovarian epithelial cells.
|
23222713 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
KLF8 expression level was significantly higher in tumors with advanced TNM stages and vascular invasion compared with that in tumors with early TNM stage and absence of vascular invasion (P<0.05).
|
23670717 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In particular, Krüppel-like factor 8 (KLF8) has been postulated to function as a tumor activator in various cancer cells, but not in glioblastoma.
|
22076119 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of KLF8 inhibited SGC7901 cell proliferation, promoted cell apoptosis, inhibited the tumorigenicity of SGC7901 cells, and significantly decreased tumor growth when the cells were injected into nude mice.
|
22081373 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcription factor Krüppel-like factor 8 (KLF8) has a role in tumor development, growth, and metastasis, but its role in hepatocellular carcinoma (HCC) is not clear.
|
20728449 |
2010 |