Parkinsonian Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
The Saccharomyces cerevisiae heat shock proteins Hsp31-34 are members of DJ-1/ThiJ/Pfpl superfamily that includes human DJ-1 (Park7), a protein involved in heritable Parkinsonism.
|
30578832 |
2019 |
Parkinsonian Disorders
|
0.600 |
Biomarker
|
group |
CTD_human |
Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells.
|
26558463 |
2015 |
Parkinsonian Disorders
|
0.600 |
Biomarker
|
group |
RGD |
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.
|
24969022 |
2014 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Mutations in parkin/PARK2, PINK1 or DJ1/PARK7 may cause early-onset parkinsonism with a low risk for cognitive decline and a pathological process usually restricted to the brainstem.
|
23462481 |
2013 |
Parkinsonian Disorders
|
0.600 |
Biomarker
|
group |
CTD_human |
Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism.
|
23046578 |
2013 |
Parkinsonian Disorders
|
0.600 |
Biomarker
|
group |
RGD |
Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat.
|
22710069 |
2012 |
Parkinsonian Disorders
|
0.600 |
Biomarker
|
group |
BEFREE |
In three forms, caused by mutations in parkin (PARK2), PINK1 (PARK6), or DJ-1 (PARK7), the phenotype is usually characterized by levodopa-responsive parkinsonism without atypical features.
|
22166450 |
2012 |
Parkinsonian Disorders
|
0.600 |
Therapeutic
|
group |
RGD |
Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7.
|
22041943 |
2011 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Mutations in the parkin, PINK1 and DJ-1 genes all result in recessive parkinsonism.
|
21317550 |
2011 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Clinical features and [11C]-CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism.
|
20607337 |
2011 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A variety of mutations in the gene encoding DJ-1 protein cause autosomal recessive early-onset parkinsonism.
|
20806408 |
2010 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism.
|
20146068 |
2010 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism.
|
18722801 |
2009 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In the latter case, mutations or changes in the protein DJ-1 have been reported to be associated with autosomal recessive, early-onset parkinsonism.
|
19425177 |
2009 |
Parkinsonian Disorders
|
0.600 |
Therapeutic
|
group |
RGD |
DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats.
|
18373560 |
2008 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In rare incidences familial forms of early-onset parkinsonism occur, and when recessively inherited, cases are often explained by mutations in either the parkin (PARK2) or PINK1 (PARK6) gene or on exceptional occasions the DJ-1 (PARK7) or ATP13A2 (PARK9) gene.
|
19087301 |
2008 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Inherited mutations in PARK7, the gene encoding DJ-1, are associated with loss of protein function and early-onset parkinsonism.
|
16894167 |
2006 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
LHGDN |
[Mutation analysis of DJ1 gene in patients with autosomal recessive early-onset Parkinsonism].
|
16331561 |
2005 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Loss-of-function mutations in the DJ-1 gene cause early-onset familial parkinsonism.
|
15721235 |
2005 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
LHGDN |
DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function.
|
14985393 |
2004 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Recently, mutations in DJ-1 (PARK7) were described as a novel cause of early-onset parkinsonism.
|
15372597 |
2004 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Mutations in the DJ-1 gene lead to autosomal recessive early-onset parkinsonism.
|
15565491 |
2004 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The DJ-1 gene is associated with autosomal recessive early-onset Parkinsonism, most likely through its role in defense against oxidative stress.
|
15542239 |
2004 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Mutant genes responsible for Parkinson's disease.
|
15018843 |
2004 |
Parkinsonian Disorders
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism.
|
12446870 |
2003 |