|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FUS1 is a tumor suppressor gene that has been found to be frequently lost in a variety of solid tumors.
|
29393096 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TUSC2 combined with anti-PD-1 induced tumor infiltrating more than NK and CD8<sup>+</sup> T cells and fewer MDSCs and Tregs than each agent alone, both in subcutaneous tumor and in lung metastases.
|
29339375 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Detection of high-grade neoplasia in air-dried cervical PAP smears by a microRNA-based classifier.
|
29328473 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Evidence to date indicates that TUSC2 behaves as a tumor suppressor in lung cancer; however, its role as a tumor suppressor for other tumor types has not been fully established.
|
28715648 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This ability to modify the tumor microenvironment suggests that TUSC2 could be added to checkpoint inhibitors to improve the treatment of lung cancer.
|
29296193 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TXNRD1 overexpression rescued tumors from AF-TUSC2-erlotinib induced apoptosis.
|
27845352 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Restoration of FUS1 function in human non-small cell lung cancer (NSCLC) cells was found to significantly inhibit tumor cell growth and modulate the chemosensitivity of lung cancer cells.
|
26081814 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Combination treatment with intravenous TUSC2 nanovesicles and erlotinib synergistically inhibited tumor growth and metastasis, and increased apoptotic activity.
|
26053020 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FUS1-hIL-12 coexpression could also obviously induce tumor cell apoptosis and inhibit tumor cell proliferation partly by higher activation of STAT1 signal pathway and upregulation of p53.
|
24410728 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We find that ectopic expression of TUSC2P and the TUSC2 3'-UTR inhibits cell proliferation, survival, migration, invasion and colony formation, and increases tumour cell death.
|
24394498 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LKB1 and FUS1 are two kinds of new tumor suppressor genes as well as early-stage genes in lung cancer.
|
24659339 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We analyzed the effects of TUSC2 re-expression on tumor cell sensitivity to the AKT inhibitor, MK2206, and explored their mutual signaling connections, in vitro and in vivo.
|
24146957 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results suggest that the FUS1 gene might be a candidate tumour suppressor gene for the treatment of oesophageal carcinoma; however, these results require confirmation in in vivo studies.
|
23617094 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells.
|
21645495 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FUS1 may act as a tumor suppressor in bone and soft-tissue sarcomas.
|
21273575 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression array studies showed that TUSC2 activates transcription of multiple genes with tumor suppressor properties and down-regulates pro-tumorigenic genes, thus supporting its role as a tumor suppressor.
|
19852844 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1.
|
19671678 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results demonstrated an important role of FUS1 in modulating chemosensitivity of lung cancer cells, and suggested that a proper combination of molecular therapeutics such as the proapoptotic tumor suppressor FUS1 and the conventional chemotherapeutic drugs such as cisplatin may be an efficient treatment strategy for human lung cancer.
|
17828283 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FUS1, a novel tumor-suppressor gene located in the chromosome 3p21.3 region, may play an important role in lung cancer development.
|
18172250 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, we showed that the observed synergistic tumor suppression by FUS1 and p53 concurred with the FUS1-mediated down-regulation of murine double minute-2 (MDM2) expression, the accumulation and stabilization of p53 protein, as well as the activation of the apoptotic protease-activating factor 1 (Apaf-1)-dependent apoptotic pathway in human NSCLC cells.
|
17234782 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1.
|
17486070 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results show that myristoylation is required for Fus1-mediated tumor-suppressing activity and suggest a novel mechanism for the inactivation of tumor suppressors in lung cancer and a role for deficient posttranslational modification in tumor suppressor-gene-mediated carcinogenesis.
|
15126327 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This result demonstrates the potent tumor suppressive activity of the FUS1 gene and is a promising therapeutic agent for treatment of primary and disseminated human lung cancer.
|
15486560 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells.
|
11593436 |
2001 |