|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the CHRNA5-A3-B4 gene cluster have been shown to be associated with nicotine dependence and alcohol use disorders (AUDs) and related traits, including the level of response (LR) to alcohol.
|
23458267 |
2013 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Surprisingly, the most convincing association (a nicotinic acetylcholine receptor <i>CHRNA5-A3-B4</i> gene cluster in nicotine dependence), with a unique attributable risk of 14%, was detected through a genome-wide association study (GWAS) on lung cancer, although lung cancer has a low heritability.
|
29302221 |
2017 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2).
|
24505444 |
2014 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this largest-ever GWAS meta-analysis for nicotine dependence and the largest-ever cross-ancestry GWAS meta-analysis for any smoking phenotype, we reconfirmed the well-known CHRNA5-CHRNA3-CHRNB4 genes and further yielded a novel association in the DNA methyltransferase gene DNMT3B.
|
28972577 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD.
|
29993116 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CHRNA5-A3-B4 haplotypes are associated with a broad range of nicotine dependence phenotypes, but these associations are not consistently moderated by age at initial smoking.
|
19436041 |
2009 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To extend the previously identified association between a single nucleotide polymorphism (SNP) in neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) and nicotine dependence to current smoking and initial smoking-experience phenotypes.
|
18783506 |
2008 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study showed a low to moderate level of ND in the Kashubians, influenced by age, sex, as well as the CHRNA5 rs16969968 variant.
|
25652844 |
2015 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We here report for the first time an association of CHRNA5-CHRNA3-CHRNB4 gene variants with cognition possibly mediating in part risk for developing ND.
|
20886544 |
2010 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.
|
22241830 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to analyse the association of smoking status and smoking-related phenotypes (included nicotine dependence) with 17 candidate genetic variants: CYP2A6*1×2, CYP2A6*2 (1799T>A) [rs1801272], CYP2A6*9 (-48T>G) [rs28399433], CYP2A6*12, CYP2A13*2 (3375C>T) [rs8192789], CYP2A13*3 (7520C>G), CYP2A13*4 (579G>A), CYP2A13*7 (578C>T) [rs72552266], CYP2B6*4 (785A>G), CYP2B6*9 (516G>T), CHRNA3 546C>T [rs578776], CHRNA5 1192G>A [rs16969968], CNR1 3764C>G [rs6928499], DRD2-ANKK1 2137G>A (Taq1A) [rs1800497], 5HTT LPR, HTR2A -1438A>G [rs6311] and OPRM1 118A>G [rs1799971].
|
22046326 |
2011 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Besides the CHRNA4, CHRNB2 and CHRNA5/A3/B4 cluster on chromosome 15, which has been investigated intensively, recent evidence from both genome-wide association studies and candidate gene-based association studies has revealed the crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence (ND).
|
27327258 |
2016 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we found that several haplotypes in CHRNA5 and CHRNA3 are nominally associated with ND in AA, EA, and pooled samples.
|
19859904 |
2010 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple genome-wide and targeted association studies reveal a significant association of variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 with nicotine dependence.
|
20808433 |
2010 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several genetic variants within the nicotinic cholinergic receptor gene cluster, CHRNA5-CHRNA3-CHRNB4 have been reported to be associated with nicotine dependence (ND), and this association has been validated in multiple studies.
|
22884254 |
2013 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report for the first time the relationship between the polymorphism of the CHRNA5 gene and the strength of nicotine addiction measured by multiple factors including the Fagerström test score.
|
21955800 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR).
|
21555077 |
2011 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
A cluster of three nicotinic acetylcholine receptor genes on chromosome 15 (CHRNA5/CHRNA3/CHRNB4) has been shown to be associated with nicotine dependence and smoking quantity.
|
19628476 |
2009 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, multiple variants in this gene cluster contribute to nicotine dependence risk, and some are also associated with functional effects on CHRNA5.
|
19706762 |
2009 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study evaluated the relationship between CHRNA5, a nicotinic receptor subunit gene, and smoking in predicting IBD-related surgery as well as the relationship between CHRNA5 and nicotine dependence.
|
29688464 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that there are at least two distinct mechanisms conferring risk for nicotine dependence and lung cancer: altered receptor function caused by a D398N amino acid variant in CHRNA5 (rs16969968) and variability in CHRNA5 mRNA expression.
|
19443489 |
2009 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs in the CHRNA5 and CHRNA3 receptor genes, previously shown to be significantly associated with ND in this sample, were replicated in the augmented analyses; they accounted for less than one percent of the genetic variance in liability to ND, which is estimated to be over 50% of the phenotypic variance.
|
21748402 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the basis of known associations with nicotine dependence, we genotyped eight single-nucleotide polymorphisms (SNPs) on chromosome 8 (three bins) in the regions of CHRNB3 and CHRNA6, and six SNPs on chromosome 15 (three bins) in the regions of CHRNA5 and CHRNA3.
|
21191315 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For severity of nicotine dependence, two SNPs in CHRNA7 (rs1909884 and rs883473), one SNP in CHRNA5 (rs680244) and the interaction of a SNP in CHRNA7 (rs2337980) with neuroticism, were included in the model (P=2.24 x 10(-7), Nagelkerke r(2)=0.40).
|
16314871 |
2006 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several independent studies show that the chromosome 15q25.1 region, which contains the CHRNA5-CHRNA3-CHRNB4 gene cluster, harbors variants strongly associated with nicotine dependence, other smoking behaviors, lung cancer and chronic obstructive pulmonary disease.
|
20584212 |
2010 |