|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR).
|
21555077 |
2011 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer.
|
20700147 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer.
|
30543688 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A CHRNA5 allele related to nicotine addiction and schizophrenia.
|
21418140 |
2011 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
A cluster of three nicotinic acetylcholine receptor genes on chromosome 15 (CHRNA5/CHRNA3/CHRNB4) has been shown to be associated with nicotine dependence and smoking quantity.
|
19628476 |
2009 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A locus at 15q24/15q25.1, which includes the nicotinic acetylcholine receptor A subunits 3 and 5 (CHRNA3 and CHRNA5) genes, has recently been associated with lung cancer risk, self-reported number of cigarettes smoked per day, and a nicotine dependence scale.
|
19010884 |
2008 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A nonsynonymous SNP in CHRNA5 previously associated to ND and several related traits, rs16969968, was genotyped in 2206 EAs (1301 men and 905 women).
|
22012472 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence.
|
19429911 |
2009 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5).
|
18519524 |
2008 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human α5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence.
|
29573323 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.
|
22241830 |
2012 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Besides the CHRNA4, CHRNB2 and CHRNA5/A3/B4 cluster on chromosome 15, which has been investigated intensively, recent evidence from both genome-wide association studies and candidate gene-based association studies has revealed the crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence (ND).
|
27327258 |
2016 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the CHRNA5-A3-B4 gene cluster have been shown to be associated with nicotine dependence and alcohol use disorders (AUDs) and related traits, including the level of response (LR) to alcohol.
|
23458267 |
2013 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consistent with this hypothesis, a number of genome-wide association studies (GWAS) and subsequent candidate gene-based associated studies investigating the genetic variants associated with nicotine dependence (ND) and smoking-related phenotypes have shed light on the CHRNA5/A3/B4 gene cluster on chromosome 15, which encodes the α5, α3, and β4 nAChR subunits, respectively.
|
25471942 |
2016 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
CPD is an important simple measure that captures in part the genetic associations of CHRNA5 and nicotine dependence, even when other more comprehensive measures of smoking behaviors are examined.
|
22102629 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For severity of nicotine dependence, two SNPs in CHRNA7 (rs1909884 and rs883473), one SNP in CHRNA5 (rs680244) and the interaction of a SNP in CHRNA7 (rs2337980) with neuroticism, were included in the model (P=2.24 x 10(-7), Nagelkerke r(2)=0.40).
|
16314871 |
2006 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further, we showed that these significant variants contribute to ND via two methylated sites, and we demonstrated significant interaction affecting ND among variants in CHRNA5/A3/B4, CHRNA7, and CHRNA4/B2/A5.
|
29666375 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we found that several haplotypes in CHRNA5 and CHRNA3 are nominally associated with ND in AA, EA, and pooled samples.
|
19859904 |
2010 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic variants located at 15q25, including those in the cholinergic receptor nicotinic cluster (CHRNA5) have been implicated in both lung cancer risk and nicotine dependence in recent genome-wide association studies.
|
22028403 |
2011 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome wide association studies revealed a relationship between development of nicotine dependence and a single-nucleotide polymorphism (SNP, rs16969968) of the nicotine acetylcholine receptor (nAChR) alpha-5 subunit gene (CHRNA5).
|
21764527 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association and large cohort studies have consistently linked several single nucleotide polymorphisms (SNPs) located in the CHRNA5/A3/B4 gene cluster to smoking behaviors and nicotine dependence.
|
25297392 |
2014 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWASs) have identified associations between the CHRNA5-CHRNA3-CHRNB4 gene cluster and smoking heaviness and nicotine dependence.
|
27871728 |
2016 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified common variation in the CHRNA5-CHRNA3-CHRNB4 and CHRNA6-CHRNB3 gene clusters that contribute to nicotine dependence.
|
22042774 |
2012 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Haplotype/diplotype analysis of rs880395 and rs1948 plus rs16969968 (a nonsynonymous CHRNA5 risk variant) in GWAS (COGEND, UW-TTURC, SAGE) yields a nicotine dependence risk profile only partially captured by rs16969968 alone.
|
27758088 |
2017 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we test the hypothesis that the nicotinic receptor genes CHRNA5 (rs16969968), CHRNA3 (rs578776), CHRNB3 (rs13277254) and CHRND (rs12466358) modify the risk for nicotine dependence associated with peer smoking.
|
20840187 |
2010 |