ADCY8, adenylate cyclase 8, 114

N. diseases: 29; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.510 Biomarker group PSYGENET Genetic markers of comorbid depression and alcoholism in women. 23278386 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.510 Biomarker group PSYGENET Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. 21042317 2012
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.510 Biomarker group PSYGENET Functional role of Calcium-stimulated adenylyl cyclase 8 in adaptations to psychological stressors in the mouse: implications for mood disorders. 20638449 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.510 Biomarker group BEFREE Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder. 19691954 2009
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.510 Biomarker group PSYGENET Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder. 19691954 2009
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.510 Biomarker group CTD_human Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder. 19691954 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease BEFREE Our data suggest that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder. 19691954 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET Our data suggest that Adcy8 might encode a translational behavioral endophenotype of bipolar disorder. 19691954 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease BEFREE These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility. 18163389 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility. 18163389 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.310 GeneticVariation disease BEFREE Polymorphisms in ADCY8 and ADCY5 and within a lincRNA are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. 23278386 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.310 Biomarker disease PSYGENET Polymorphisms in ADCY8 and ADCY5 and within a lincRNA are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. 23278386 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 GeneticVariation disease BEFREE Polymorphisms in ADCY8 and ADCY5 and within a lincRNA are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. 23278386 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 Biomarker disease PSYGENET Polymorphisms in ADCY8 and ADCY5 and within a lincRNA are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression. 23278386 2013
CUI: C0011875
Disease: Diabetic Angiopathies
Diabetic Angiopathies 		0.300 Biomarker disease CTD_human Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes. 25381014 2015
CUI: C0025945
Disease: Microangiopathy, Diabetic
Microangiopathy, Diabetic 		0.300 Biomarker disease CTD_human Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes. 25381014 2015
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. 16914643 2006
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. 16914643 2006
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. 16914643 2006
CUI: C0751217
Disease: Hyperkinesia, Generalized
Hyperkinesia, Generalized 		0.300 Biomarker phenotype CTD_human Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. 16914643 2006
CUI: C3887506
Disease: Hyperkinesia
Hyperkinesia 		0.300 Biomarker phenotype CTD_human Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. 16914643 2006
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.300 GeneticVariation disease UNIPROT
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.100 GeneticVariation disease GWASCAT Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study. 31178898 2019
CUI: C0013264
Disease: Muscular Dystrophy, Duchenne
Muscular Dystrophy, Duchenne 		0.100 GeneticVariation disease GWASCAT Long-range genomic regulators of THBS1 and LTBP4 modify disease severity in duchenne muscular dystrophy. 30014611 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017