|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
Ectopic expression of miR-34a and miR-182 in LMTK3-overexpressing cell lines (MCF7-LMTK3 and MDA-MB-231-LMTK3) inhibits breast cancer proliferation, invasion and migration.
|
26739063 |
2016 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We then analyzed the impact of LMTK3 mRNA expression on the prognosis of breast cancer according to estrogen receptor alpha status.
|
25163465 |
2014 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.
|
26212333 |
2015 |
|
Malignant neoplasm of breast
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) was recently identified as an estrogen receptor (ER)-α modulator related to endocrine therapy resistance, and its polymorphisms rs9989661 (T>C) T/T genotype and rs8108419 (G>A) G/G or A/G genotype predicted improved outcomes in breast cancer.
|
23918832 |
2013 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
These results reveal a direct role of MIR2052HG in LMTK3 regulation and raise the possibilities of targeting MIR2052HG or LMTK3 in ERα-positive breast cancer.
|
30944027 |
2019 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In contrast to other modulators of ERα activity, LMTK3 seems to have been subject to Darwinian positive selection, a noteworthy result given the unique susceptibility of humans to ERα+ breast cancer.
|
21602804 |
2011 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
LMTK3 acts as key biomarker for ERα positive breast cancer and identified as novel drug target for breast cancer.
|
29719770 |
2018 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Using both 2D and 3D tissue culture models, we found that overexpression of LMTK3 decreased the sensitivity of breast cancer cell lines to cytotoxic (doxorubicin) treatment.
|
29540829 |
2018 |
|
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We then analyzed the impact of LMTK3 mRNA expression on the prognosis of breast cancer according to estrogen receptor alpha status.
|
25163465 |
2014 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Ectopic expression of miR-34a and miR-182 in LMTK3-overexpressing cell lines (MCF7-LMTK3 and MDA-MB-231-LMTK3) inhibits breast cancer proliferation, invasion and migration.
|
26739063 |
2016 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
These results reveal a direct role of MIR2052HG in LMTK3 regulation and raise the possibilities of targeting MIR2052HG or LMTK3 in ERα-positive breast cancer.
|
30944027 |
2019 |
|
Breast Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) was recently identified as an estrogen receptor (ER)-α modulator related to endocrine therapy resistance, and its polymorphisms rs9989661 (T>C) T/T genotype and rs8108419 (G>A) G/G or A/G genotype predicted improved outcomes in breast cancer.
|
23918832 |
2013 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.
|
26212333 |
2015 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
LMTK3 acts as key biomarker for ERα positive breast cancer and identified as novel drug target for breast cancer.
|
29719770 |
2018 |
|
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In contrast to other modulators of ERα activity, LMTK3 seems to have been subject to Darwinian positive selection, a noteworthy result given the unique susceptibility of humans to ERα+ breast cancer.
|
21602804 |
2011 |
|
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Using both 2D and 3D tissue culture models, we found that overexpression of LMTK3 decreased the sensitivity of breast cancer cell lines to cytotoxic (doxorubicin) treatment.
|
29540829 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer.
|
26739063 |
2016 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer.
|
26212333 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer.
|
26212333 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer.
|
26739063 |
2016 |
|
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicated that LMTK3 knockdown retards the growth of thyroid cancer cells partly through inhibiting proliferation, invasion, migration and inducing apoptosis in SW579 cells.
|
28260052 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because different predominant ER distributions link to breast and gastric cancer and little is known of the prognostic role of LMTK3 in gastric cancer, this study was carried out to clarify the prognostic role of these polymorphisms in gastric cancer.
|
23918832 |
2013 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma.
|
30242244 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The protein and mRNA expression of LMTK3 was markedly higher in thyroid cancer patients compared with patients with benign thyroid tumors.
|
28260052 |
2017 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Behavioral analysis of Lmtk3-KO mice revealed a number of abnormalities that have been linked to psychiatric disease such as hyper-sociability, PPI deficits and cognitive dysfunction.
|
31310731 |
2019 |