Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In contrast to other modulators of ERα activity, LMTK3 seems to have been subject to Darwinian positive selection, a noteworthy result given the unique susceptibility of humans to ERα+ breast cancer.
|
21602804 |
2011 |
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In contrast to other modulators of ERα activity, LMTK3 seems to have been subject to Darwinian positive selection, a noteworthy result given the unique susceptibility of humans to ERα+ breast cancer.
|
21602804 |
2011 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Silencing of LMTK3 reduced tumor volume in an orthotopic mouse model and abrogated proliferation of ERα+ but not ERα- cells, indicative of its role in ERα activity.
|
21602804 |
2011 |
Malignant neoplasm of breast
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) was recently identified as an estrogen receptor (ER)-α modulator related to endocrine therapy resistance, and its polymorphisms rs9989661 (T>C) T/T genotype and rs8108419 (G>A) G/G or A/G genotype predicted improved outcomes in breast cancer.
|
23918832 |
2013 |
Breast Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) was recently identified as an estrogen receptor (ER)-α modulator related to endocrine therapy resistance, and its polymorphisms rs9989661 (T>C) T/T genotype and rs8108419 (G>A) G/G or A/G genotype predicted improved outcomes in breast cancer.
|
23918832 |
2013 |
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because different predominant ER distributions link to breast and gastric cancer and little is known of the prognostic role of LMTK3 in gastric cancer, this study was carried out to clarify the prognostic role of these polymorphisms in gastric cancer.
|
23918832 |
2013 |
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because different predominant ER distributions link to breast and gastric cancer and little is known of the prognostic role of LMTK3 in gastric cancer, this study was carried out to clarify the prognostic role of these polymorphisms in gastric cancer.
|
23918832 |
2013 |
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We then analyzed the impact of LMTK3 mRNA expression on the prognosis of breast cancer according to estrogen receptor alpha status.
|
25163465 |
2014 |
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We then analyzed the impact of LMTK3 mRNA expression on the prognosis of breast cancer according to estrogen receptor alpha status.
|
25163465 |
2014 |
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.
|
26212333 |
2015 |
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.
|
26212333 |
2015 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The LMTK3/KAP1 interaction is stabilized by PP1α, which suppresses KAP1 phosphorylation specifically at LMTK3-associated chromatin regions, inducing chromatin condensation and resulting in transcriptional repression of LMTK3-bound tumor suppressor-like genes.
|
26212333 |
2015 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In summary, we propose a model where a scaffolding function of nuclear LMTK3 promotes cancer progression through chromatin remodeling.
|
26212333 |
2015 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer.
|
26212333 |
2015 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer.
|
26212333 |
2015 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer.
|
26212333 |
2015 |
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer.
|
26212333 |
2015 |
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
Ectopic expression of miR-34a and miR-182 in LMTK3-overexpressing cell lines (MCF7-LMTK3 and MDA-MB-231-LMTK3) inhibits breast cancer proliferation, invasion and migration.
|
26739063 |
2016 |
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Ectopic expression of miR-34a and miR-182 in LMTK3-overexpressing cell lines (MCF7-LMTK3 and MDA-MB-231-LMTK3) inhibits breast cancer proliferation, invasion and migration.
|
26739063 |
2016 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Interestingly, miR-34a and miR-182 directly bind to the 3'UTR of LMTK3 mRNA and consequently inhibit both its stability and translation, acting as tumour suppressor-like miRNAs.
|
26739063 |
2016 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer.
|
26739063 |
2016 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer.
|
26739063 |
2016 |
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer.
|
26739063 |
2016 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Lemur tyrosine kinase-3 (LMTK3) is a member of the serine/threonine tyrosine kinase family, which is thought to be involved in tumor progression and prognosis.
|
28260052 |
2017 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer.
|
28260052 |
2017 |