FBXO32, F-box protein 32, 114907

N. diseases: 68; N. variants: 4
Disease: Cachexia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia 		0.030 Biomarker phenotype BEFREE Although many negative regulators (atrogin-1, muscle ring finger-1, nuclear factor-kappaB (NF-κB), myostatin, etc.) have been proposed to enhance protein degradation during both sarcopenia and cachexia, the adaptation of these mediators markedly differs within both conditions. 28101649 2017
CUI: C0006625
Disease: Cachexia
Cachexia 		0.030 Biomarker phenotype BEFREE These findings suggest that both increased Atrogin-1 and the presence of unique post-translational modifications may serve as a surrogate marker specific for cachexia. 28979816 2017
CUI: C0006625
Disease: Cachexia
Cachexia 		0.030 AlteredExpression phenotype BEFREE Levels of FBXO32 (Atrogin-1), ActRIIB and myostatin were significantly changed in the irradiated cachectic NHP compared to the non-irradiated NHP. 27029502 2016