FBXO32, F-box protein 32, 114907

N. diseases: 68; N. variants: 4
Disease: Sarcopenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0872084
Disease: Sarcopenia
Sarcopenia 		0.020 Biomarker phenotype BEFREE Although many negative regulators (atrogin-1, muscle ring finger-1, nuclear factor-kappaB (NF-κB), myostatin, etc.) have been proposed to enhance protein degradation during both sarcopenia and cachexia, the adaptation of these mediators markedly differs within both conditions. 28101649 2017
CUI: C0872084
Disease: Sarcopenia
Sarcopenia 		0.020 AlteredExpression phenotype BEFREE Sarcopenia in quadriceps muscles also coincided with increased protein levels for Igf1 receptor, Akt and ribosomal protein S6 (Rps6) with increased phosphorylation of Rps6 (Ser235/236) and elevated Murf1 mRNA and protein, but not Fbxo32: many of these changes are also linked to denervation. 24836906 2014