FBXO32, F-box protein 32, 114907

N. diseases: 68; N. variants: 4
Disease: Chronic Kidney Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.030 GeneticVariation group BEFREE In attempting to identify potential mechanisms involved in this correlation, we show increased expressions of E1, E214K, E3αI, E3αII, MuRF-1, and atrogin-1 in skeletal muscle tissue obtained from an animal model of chronic kidney disease. 29202452 2017
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.030 Biomarker group BEFREE Compared with sham mice, the expression of interleukin-6 and atrophy-related factors such as myostatin and atrogin-1 was increased in the skeletal muscle of CKD mice, whereas muscular Akt phosphorylation was decreased. 28608457 2017
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.030 AlteredExpression group BEFREE Knockdown of SCP4 significantly suppressed FoxO1/3a-mediated expression of Atrogin-1 and MuRF-1 and prevented muscle wasting in mice with CKD. 28506762 2017