RASGRP4, RAS guanyl releasing protein 4, 115727

N. diseases: 12; N. variants: 1
Disease: Leukemia, Mast-Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023461
Disease: Leukemia, Mast-Cell
Leukemia, Mast-Cell 		0.010 GeneticVariation disease LHGDN RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. 11956218 2002