|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GRIN2B may be associated with schizophrenia and interaction effects of the polymorphisms in hsa-miR-219, CAKM2G, GRIN2B and GRIN3A may confer susceptibility to schizophrenia in the Chinese Han population.
|
26257337 |
2015 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
A population-specific uncommon variant in GRIN3A associated with schizophrenia.
|
23237318 |
2013 |
|
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
A population-specific uncommon variant in GRIN3A associated with schizophrenia.
|
23237318 |
2013 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
We searched for genetic variants in the putative core promoter region and all the exons (including UTR ends) of the GRIN3A gene in 333 Han Chinese patients with schizophrenia and 369 control subjects from Taiwan using direct polymerase chain reaction (PCR) autosequencing, and assessed their association with schizophrenia.
|
19665356 |
2009 |
|
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
We searched for genetic variants in the putative core promoter region and all the exons (including UTR ends) of the GRIN3A gene in 333 Han Chinese patients with schizophrenia and 369 control subjects from Taiwan using direct polymerase chain reaction (PCR) autosequencing, and assessed their association with schizophrenia.
|
19665356 |
2009 |
|
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
As was the case in schizophrenia, no changes in NR3A expression were observed in the inferior temporal cortex in bipolar disorder.
|
15474907 |
2004 |
|
Schizophrenia
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
As was the case in schizophrenia, no changes in NR3A expression were observed in the inferior temporal cortex in bipolar disorder.
|
15474907 |
2004 |
|
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
As was the case in schizophrenia, no changes in NR3A expression were observed in the inferior temporal cortex in bipolar disorder.
|
15474907 |
2004 |
|
Bipolar Disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
As was the case in schizophrenia, no changes in NR3A expression were observed in the inferior temporal cortex in bipolar disorder.
|
15474907 |
2004 |
|
Erectile dysfunction
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.
|
19295509 |
2009 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Nicotine Dependence
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We performed an association study of 16 single nucleotide polymorphisms (SNPs) in GRIN3A with ND in 2616 Chinese individuals.
|
30741440 |
2020 |
|
Huntington Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data provide proof-of-concept for GluN3A silencing as a beneficial strategy to prevent or reverse corticostriatal disconnectivity and motor impairment in HD and support the use of RNAi-based or small-molecule approaches for harnessing this therapeutic potential.
|
29914757 |
2018 |
|
Huntington Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Suppressing the GluN3A reactivation corrected the NMDAR hyperfunction and prevented the full range of HD signs and symptoms in mouse models, encouraging efforts to develop GluN3A-selective antagonists and/or explore alternative therapeutic approaches to block GluN3A expression.
|
25686081 |
2015 |
|
Nicotine Dependence
|
0.020 |
Biomarker
|
disease |
BEFREE |
We concluded that GRIN3A represents a strong candidate for involvement in the etiology of ND and warrants further investigation in independent samples.
|
20084518 |
2010 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases.
|
30734226 |
2019 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Of these genes, GluN3A has been the most studied, and it has been revealed to play crucial roles in the etiology of addictions.
|
29429049 |
2018 |
|
Memory impairment
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
GluN3A KO mice displayed abnormal food preference in the social transmission of food preference task and low social interaction activity in the five-trial social memory test, but without social memory deficits.
|
29554474 |
2018 |
|
Congenital Disorders of Glycosylation
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We also found (either using a panel of inhibitors or by studying human fibroblasts derived from patients with a congenital disorder of glycosylation) that <i>N</i>-glycan remodeling is not required for the surface delivery of GluN3A-containing NMDARs.
|
29915530 |
2018 |
|
Benign neoplasm of oral cavity
|
0.010 |
Biomarker
|
group |
BEFREE |
The peptide mass at 2,316 Da of Notch1 appeared in early-stage OM and benign oral tumors while the peptide mass at 2,505 Da of glutamate ionotropic receptor N-methyl-D-aspartate type subunit 3A (GRIN3A) was identified in all groups.
|
30001383 |
2018 |
|
Drug Dependence
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, unlike our earlier finding of drug addiction, the mRNA expression levels of GluN3A and GluN3B subunits in PBLs of game addicts are reduced and unchanged, respectively, compared with control subjects.
|
29788757 |
2018 |
|
Heroin Dependence
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that GRIN3A rs17189632 and GRIN3B rs2240158 may contribute to the susceptibility of heroin addiction.
|
27542340 |
2016 |
|
Congenital macrodactylia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GRIN3A and MAPT stimulate nerve overgrowth in macrodactyly.
|
27840953 |
2016 |
|
Delirium
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the genetic variations of NR3A subunit of NMDA receptor may be a predisposing factor to delirium among the Polish population of cardiac surgery patients.
|
25041634 |
2015 |