|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
A 3-SNP GRS and MetRS were generated in the EPIC-Norfolk cohort (n = 20,074) based on 3 SNPs in LPL and APOA5 or the number of Metabolic Syndrome criteria present (maximum 5), respectively.
|
30910668 |
2020 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females.
|
31170924 |
2019 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
Further studies, including other polymorphisms, are required to investigate the involvement of APOA5 gene in the genetic susceptibility to MetS in the pediatric age group.
|
29504307 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variants in APOA5 and ADIPOQ Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention.
|
30472712 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein A5 Q139X, lipoprotein lipase (LPL) Hinf I, human paraoxonase 1 (PON1) 192Arg/Gln, cholesteryl ester transfer protein (CETP) Taq1B, adiponectin 45T>G and leptin (LEP) 25CAG were genotyped by real-time polymerase chain reaction in participants with and without MetS.
|
30381540 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this review, we focus on the association of gene and protein of apoA5 with obesity and metabolic syndrome, and provide new insights into the physiological role of apoA5 in humans, giving a potential therapeutic target for obesity and associated disorders.
|
30053818 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.
|
28371326 |
2017 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
For the MetS-related and heritable taxa, we further investigated their associations with the apolipoprotein A-V gene (<i>APOA5</i>) single nucleotide polymorphism (SNP) rs651821, which is known to be associated with triglyceride levels and MetS.
|
27053630 |
2017 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data showed an association of MetS at the genome-wide significance level (<i>P</i> < 8.6 x 10<sup>-8</sup>) with two SNPs, including the rs662799 SNP in the apolipoprotein A5 (<i>APOA5</i>) gene and the rs16944558 SNP in the collectin subfamily member 12 (<i>COLEC12</i>) gene.
|
29212154 |
2017 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Assuming that genetic background also plays a role in their susceptibility for cardiovascular diseases, we hypothesized that APOA5 gene polymorphisms, an important role-player in lipid metabolism and in the development of metabolic syndrome and cardio/cerebrovascular events, may also be involved.
|
28102463 |
2017 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian-specific common variant, was found to be associated with MetS (P<sub>combined</sub> = 9.7 × 10<sup>-22</sup> ) in Han Chinese.
|
28371326 |
2017 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The T-C, C-T, and C-C haplotypes of the ApoA5 -1131T>C and -12,238T>C polymorphisms were associated with an increased risk for MetS (p < 0.001, p = 0.001, and p < 0.001, respectively).
|
26760709 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data showed a nominal association of MetS with the APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, and LIPA rs1412444 single nucleotide polymorphisms (SNPs).
|
27827461 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to determine the association of single nucleotide polymorphisms including: rs662799, rs3135506 and rs2075291 in the apolipoprotein A-V (APOA5) gene in relation to MetS component like triglyceride and HDL-C level in Tehran Lipid and Glucose Study (TLGS).
|
26702748 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome.
|
26824674 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We found that rs662799 near APOA5 and rs769450 in APOE had significant association with MetS and its components.
|
26365620 |
2015 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2.
|
25646961 |
2015 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have identified the novel APOA5-ZNF259 haplotype manifesting sex-dependent effects on elevation of the TG:HDL-C ratio as well as the increased risk for MS.
|
24618354 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Results of analysis of multiple regression models showed that the ApoA5 -1131C carriers showed an increased incidence of MS (OR=1.73, 95% CI: 1.41-2.11).
|
24161374 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients.
|
24709297 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Population studies conducted in various countries have demonstrated an association between single nucleotide polymorphisms (SNPs) in ApoA5 and the increased risk to cardiovascular disease and metabolic syndrome (including diabetes and obesity).
|
23000317 |
2013 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of apolipoprotein A5 gene -1131T>C polymorphism with the risk of metabolic syndrome in Korean subjects.
|
23509746 |
2013 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis.
|
23468858 |
2013 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two common variants of ApoA5 (namely -1131T>C in the promoter region and c.56C>G in the coding region) with the risk of MetS were analyzed.
|
22905904 |
2012 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of APOA5 and BTN2A1 may synergistically affect the prevalence of dyslipidemia in East Asian populations and of MetS in Japanese individuals.
|
22576629 |
2012 |