|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Heat shock protein family A member 12B (HSPA12B) protein was negatively regulated by uc.454 at the posttranscriptional level by dual-luciferase reporter assay and affected the expressions of Bcl-2 family members, which finally induced LC apoptosis.
|
30195756 |
2018 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The uc.454/HSPA12B axis furthers our understanding of the molecular mechanisms involved in tumor apoptosis, which may potentially serve as a therapeutic target for lung carcinoma.
|
30195756 |
2018 |
|
Middle Cerebral Artery Occlusion
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we have investigated its effects on functional recovery at chronic phase of ischaemic stroke.Ischaemic stroke was induced by 60 min. of middle cerebral artery occlusion in transgenic mice with overexpression of HSPA12B (HSPA12B Tg) and wild-type littermates (WT).
|
29411514 |
2018 |
|
Ischemic stroke
|
0.020 |
Biomarker
|
disease |
BEFREE |
HSPA12B promotes functional recovery after ischaemic stroke through an eNOS-dependent mechanism.
|
29411514 |
2018 |
|
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Heat shock protein family A member 12B (HSPA12B) protein was negatively regulated by uc.454 at the posttranscriptional level by dual-luciferase reporter assay and affected the expressions of Bcl-2 family members, which finally induced LC apoptosis.
|
30195756 |
2018 |
|
Septicemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The mice were treated by nasal inhalation of 2-OMe-modified HSPA12B siRNA or NC siRNA.Sepsis was induced by CLP.
|
28535510 |
2017 |
|
Sepsis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The mice were treated by nasal inhalation of 2-OMe-modified HSPA12B siRNA or NC siRNA.Sepsis was induced by CLP.
|
28535510 |
2017 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The present study identified HSPA12B as a novel facilitator of lung tumor growth and a potential therapeutic target for the treatment of lung cancer.
|
25909170 |
2015 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The present study identified HSPA12B as a novel facilitator of lung tumor growth and a potential therapeutic target for the treatment of lung cancer.
|
25909170 |
2015 |
|
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The present study identified HSPA12B as a novel facilitator of lung tumor growth and a potential therapeutic target for the treatment of lung cancer.
|
25909170 |
2015 |
|
Middle Cerebral Artery Occlusion
|
0.020 |
Biomarker
|
disease |
BEFREE |
Transgenic mice overexpressing human HSPA12B (Tg) and wild-type littermates (WT) were subjected to 60 min of middle cerebral artery occlusion to induce ischemia and followed by reperfusion (I/R).
|
23046810 |
2013 |
|
Ischemic stroke
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results suggest that HSPA12B may have a therapeutic potential against ischemic stroke.
|
23046810 |
2013 |
|
Septicemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism.
|
20733008 |
2011 |
|
Sepsis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism.
|
20733008 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that HSPA12B overexpression increased resistance to CDDP in NSCLC cells <i>in vivo</i> and <i>in vitro</i> by promoting cell growth and inhibiting CDDP-induced apoptosis.
|
29556279 |
2018 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The effect of HSPA12B overexpression on chemoresistance in mice bearing A549 xenografted tumors was then determined via stable HSPA12B transfection.
|
29556279 |
2018 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
The data suggest that HSPA12B promoted functional recovery and survival after stroke in an eNOS-dependent mechanism.
|
29411514 |
2018 |
|
B-Cell Lymphomas
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Finally, the effects of HSPA12B overexpression on the phosphorylation of protein kinase B (Akt) and nuclear factor-κB inhibitor α (IκBα), and the expression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) and the pro-apoptotic protein cleaved caspase-3 were determined by western blot analysis.
|
29556279 |
2018 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSPA12B) in a streptozotocin-induced diabetic rat subjected to myocardial infarction.
|
28281242 |
2017 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings reveal that HSPA12B overexpression interacts with AKAP12 and downregulate TXNIP in diabetic rats following acute MI.
|
28281242 |
2017 |
|
Acute myocardial ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent Mechanism.
|
27644317 |
2016 |
|
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Celecoxib, a selective Cox-2 inhibitor, suppressed the HSPA12B-induced increase in lung tumor burden.
|
25909170 |
2015 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the association between genetic variation in chromosomal region 20p13-p12 (ADAM33 and flanking genes ATRN, GFRA4, SIGLEC1 and HSPA12B) and asthma.
|
23331525 |
2013 |