CLU, clusterin, 1191

N. diseases: 412; N. variants: 14
Disease: Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 Biomarker disease BEFREE Targeting clusterin induces apoptosis, reduces growth ability, invasion and mediates sensitivity to chemotherapy in human cancer in human osteosarcoma cells. 31433751 2020
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 Biomarker disease BEFREE The ERK/eIF4F/Bcl-XL pathway mediates SGP-2 induced osteosarcoma cells apoptosis in vitro and in vivo. 25025927 2014
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 Biomarker disease BEFREE All osteosarcomas were positive for HSP90 and clusterin to a variable extent. 23063503 2013
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 AlteredExpression disease BEFREE Antibody-mediated neutralization of the extracellular CLU, or silencing of CLU gene expression via small interfering RNA (siRNA) partially sensitized KH OS R2 cells to the drugs assayed. 17096323 2007
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.050 PosttranslationalModification disease BEFREE Here, we describe siRNA-mediated CLU gene silencing in osteosarcoma and prostate human cancer cells and illustrate that CLU mRNA is amenable to siRNA-mediated degradation. 14996747 2004