Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association of two tryptophan hydroxylase 2 (TPH2) polymorphisms and treatment response in electroconvulsive therapy (ECT) and the risk of depression was studied.
|
19679166 |
2009 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men.
|
19548263 |
2010 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that BH<sub>4</sub> treatment of HPA toward systemic L-Phe lowering reverses elevated brain L-Phe content but the recovery of TPH2 protein and activity as well as serotonin levels is suboptimal, indicating that patients with mild HPA and mood problems (depression or anxiety) treated with the current diet may benefit from supplementation with BH<sub>4</sub> and 5-OH-tryptophan.
|
29520738 |
2018 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders.
|
23510446 |
2013 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression.
|
19125159 |
2010 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphisms involved in the tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), serotonin transporter, monoamine oxidase A (MAOA) and brain-derived neurotrophic factor (BDNF) were investigated in a naturalistic inpatient study of the German research network on depression.
|
23063133 |
2013 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here we use chronic multicircuit neurophysiological recordings to characterize functional interactions across cortical and limbic circuits in mice engineered to express a human loss-of-function depression allele Tph2-(R441H) [Tph2 knockin (Tph2KI)].
|
23467366 |
2013 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We chose several genetic variants within candidate genes (SLC6A4, TPH2, HTR1A) that have been previously found to provide some evidence of association with depression outcomes.
|
22868061 |
2012 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It was recently reported that the TPH2 haplotype was linked to depression in humans.
|
16203956 |
2005 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
5-HTT and TPH2 variations did not contribute significantly to the prediction of interferon-induced depression by HTR1A (sensitivity, 35.9%; specificity, 84.0%).
|
17408646 |
2007 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although TPH-2 is often implicated in the pathophysiology of depression, few studies have applied a genetic and imaging technique to investigate the mechanism of early wakening symptom in MDD.
|
30519155 |
2018 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Association between tryptophan hydroxylase-2 gene and late-onset depression.
|
21873838 |
2011 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The participation of estradiol in depression may include regulation of the expression of tryptophan hydroxylase-2, monoamine oxidase A and B, serotonin transporter and serotonin-1A receptor.
|
29956632 |
2019 |
Depressive disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, there was a significant correlation between the methylation status of the TPH2 promoter and depression, hopelessness and cognitive impairment in the MDD + suicide group.
|
25955598 |
2015 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, the T/T homozygote of c.-1668T>A-TPH1, the G/T heterozygote and T allele of c.-844G>T-TPH2, and the C/C homozygote and C allele of c.-1449C>A-TPH2 decreased the risk of development of depressive disorders.
|
29314569 |
2018 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study is to investigate the involvement of tryptophan hydroxylase 2 (Tph2) H3K9 acetylation (H3K9ac) modification on PS-induced depression-like behavior in juvenile offspring rats (JOR).
|
29625215 |
2018 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population.
|
26057341 |
2015 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this review, we will critically assess the evidence for 5-HT deficiency in depression and the possible role of polymorphisms in the Tph2 gene as a causal factor in 5-HT deficiency, the latter investigated from a clinical as well as preclinical angle.
|
22826344 |
2012 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we appraise the genetic and neurobiological evidence to illustrate the critical role of TPH2 in central 5-HT system function and in the pathophysiology of a wide spectrum of disorders of cognitive control and emotion regulation, ranging from depression to attention-deficit/hyperactivity disorder (ADHD), a phenotype commonly associated with difficulties in the control of emotion and with a high co-morbidity of depression.
|
21257271 |
2011 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haplotype block in the promoter region of TPH2 showed significant associations with depression values during pregnancy and 6-8 months afterwards.
|
22721547 |
2012 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.
|
23547810 |
2013 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The effect of TPH2 haplotypes on risk-taking was independent of current depression and anxiety symptoms, neuroticism and impulsiveness scores.
|
20043001 |
2010 |
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
While genetic association and mRNA expression studies implicate the tryptophan hydroxylase isoform-1 gene (TPH1) in depression and suicidality, the TPH1 gene is 150-fold less expressed in mouse brain than TPH2.
|
15941494 |
2006 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life.
|
25214390 |
2014 |