Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
According to our meta-analysis, TPH2 polymorphisms show strongest associations with mood disorders, suicide (attempt) and schizophrenia.
|
29775696 |
2018 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia.
|
28084537 |
2017 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis.
|
25073638 |
2014 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While the TPH1 gene has been found to be associated with schizophrenia, studies focusing on TPH2 variants did not yield conclusive results for schizophrenia or the response to antipsychotic medication.
|
22655589 |
2012 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the associations of HTR1A C-1019G, HTR2A-1438A/G, TPH1 218A/C, and TPH2-703G/T variants with schizophrenia.
|
21399903 |
2011 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.
|
21396719 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
To further clarify the role of TPH2 in this disease, we performed a case-control study to examine the association of the TPH2 gene with schizophrenia and its clinical features.
|
20938755 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
A total of 202 patients with schizophrenia and 165 normal controls were genotyped for HTR1A C-1019G, HTR2A-1438A/G, TPH1 218A/C, and TPH2-703G/T single nucleotide polymorphisms (SNPs).
|
21399903 |
2011 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, TPH2 polymorphism was not associated with schizophrenia.
|
20623453 |
2010 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that neither common genetic variations of TPH1 nor TPH2 are likely to contribute to the genetic susceptibility to schizophrenia in Japanese population.
|
20144688 |
2010 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TPH2 genotypes were determined in 69 subjects with a diagnosis of schizophrenia or bipolar disorder, among which 22 died by suicide.
|
16436194 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia.
|
15840421 |
2005 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that bipolar disorder and schizophrenia are associated with abnormal levels of TPH2 mRNA in the brain.
|
16240163 |
2005 |