CMA1, chymase 1, 1215

N. diseases: 157; N. variants: 2
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 AlteredExpression disease BEFREE Through bioinformatics analysis, the high expression of HIF-1α, MCT1 or MCT4 indicate a poor prognosis in glioblastoma. 29928884 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE We aim to explore current therapies focused on MCT1 and MCT4 and propose future studies to better understand their role in GBM to optimize future treatment regimens. 30416849 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE Thus, targeting MCT1 in both tumor cells and brain EC may be a promising therapeutic strategy for the treatment of GBM. 28762551 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE Our findings indicate that MCT1 is involved in the maintenance of GSCs and is a promising therapeutic target for glioblastoma. 26902636 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE The effect of CHC (MCT inhibitor) and MCT1 silencing was assessed in in vitro and in vivo glioblastoma models. 23258846 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 AlteredExpression disease BEFREE MCT 1 and 2 were the primary isoforms expressed in human glioblastoma multiforme and glioma-derived cell lines. 15574223 2004