CCR3, C-C motif chemokine receptor 3, 1232

N. diseases: 149; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma. 17845580 2007
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found. 11307756 2001
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease GWASDB Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. 21150878 2011
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE Although polymorphisms in CCR3 were not associated with asthma susceptibility, the CCR3 haplotype ht2 showed a negative gene dose effect on the eosinophil count (P = .003-.009). 17983872 2007
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease LHGDN But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma. 17845580 2007
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.320 GeneticVariation group BEFREE Further study will be of interest to test whether CCR3-C218S variation or any of the CCR4 variations has a significant role in rendering susceptibility to immunological diseases or resistance to HIV infection. 11196669 1999
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.320 GeneticVariation group BEFREE The CCR3 rs3091250 [TT, adjusted odds ratio (AOR): 2.147, 95% confidence interval (CI) 1.076-4.287, P = 0.030], CCR8 rs2853699 (GC/CC, AOR: 1.577, 95% CI 1.049-2.371, P = 0.029), CXCL10 rs56061981 (CT/TT, AOR: 1.819, 95% CI 1.074-3.081, P = 0.026) and CCL22 rs4359426 (CA/AA, AOR: 1.887, 95% CI 1.021-3.487, P = 0.043) polymorphisms were associated with susceptibility to HIV infection. 28358741 2017
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.140 GeneticVariation disease GWASCAT Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis. 26546613 2016
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.130 GeneticVariation group BEFREE In this study, variation screening of the entire coding regions of CCR3 and CCR4 was performed, and possible association with several autoimmune diseases was tested, using the genomic DNA from 304 Japanese healthy individuals and 272 Japanese patients with rheumatic diseases. 11196669 1999
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.130 GeneticVariation group BEFREE Children with multiple autoimmune diseases showed nominal association with RGS1 (rs2816316), and children coming from an autoimmune family with rs11711054 (CCR3-CCR5). 29182645 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.130 GeneticVariation group GWASDB Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. 21383967 2011
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease GWASDB Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. 22057235 2011
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease GWASDB Multiple common variants for celiac disease influencing immune gene expression. 20190752 2010
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease GWASCAT Multiple common variants for celiac disease influencing immune gene expression. 20190752 2010
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease GWASCAT Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. 22057235 2011
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease GWASCAT Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis. 26546613 2016
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease GWASDB Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. 24999842 2014
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease GWASCAT Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. 24999842 2014
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.130 GeneticVariation disease BEFREE This meta-analysis provides robust estimates that IL18RAP rs917997 and CCR3 rs6441961 are potential risk factors for celiac disease in European populations. 26289103 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.130 GeneticVariation disease GWASDB Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. 22190364 2011
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.120 GeneticVariation disease BEFREE First stage analysis showed that ten SNPs, located in 3'UTR, 5'UTR in CCR1 or 5'UTR in CCR3, were significantly associated with Behçet's disease (P(c) = 0.018 to 1.3 × 10(-3)). 22829007 2012
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.120 GeneticVariation disease GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.120 GeneticVariation disease GWASCAT Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases
0.110 GeneticVariation group BEFREE Further study will be of interest to test whether CCR3-C218S variation or any of the CCR4 variations has a significant role in rendering susceptibility to immunological diseases or resistance to HIV infection. 11196669 1999
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases
0.110 GeneticVariation group GWASDB Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. 21383967 2011