CCR3, C-C motif chemokine receptor 3, 1232

N. diseases: 149; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.140 Biomarker disease BEFREE By contrast, CCR3+ T lymphocytes were absent from tissues that lack eosinophils, as demonstrated for normal skin and rheumatoid arthritis synovium. 9480044 1997
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 Biomarker disease BEFREE The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP-1beta, which is a CCR5 ligand. 9024664 1997
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.040 AlteredExpression disease BEFREE Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. 9323208 1997
CUI: C0007684
Disease: Central Nervous System Infection
Central Nervous System Infection 		0.010 Biomarker group BEFREE CCR3 appears critical in central nervous system infection. 9334732 1997
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.010 Biomarker disease BEFREE Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma. 9323208 1997
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 Biomarker disease BEFREE Thus, CCR5, not CCR3, is an essential receptor for HIV-1 infection of monocytes. 9525662 1998
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.040 Biomarker disease BEFREE We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. 9765485 1998
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.040 Biomarker disease BEFREE Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia. 9525662 1998
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.010 Biomarker group BEFREE The beta chemokines and antibodies to CCR3 failed to affect viral infection of both macrophage cell types. 9525662 1998
CUI: C0004096
Disease: Asthma
Asthma 		0.400 Biomarker disease BEFREE The purpose of this study was to enumerate CD34(+) cell numbers in blood and bone marrow from atopic asthmatics and control subjects and to test the hypothesis that there is an increased bone marrow pool of CCR3(+) eosinophils in patients with atopic asthma, as compared with control subjects. 9893192 1999
CUI: C0004096
Disease: Asthma
Asthma 		0.400 Biomarker disease BEFREE We examined the expression of eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), MCP-4, and CCR3 in the bronchial mucosa from atopic (AA) and nonatopic (intrinsic; NAA) asthmatics and compared our findings with atopic (AC) and nonatopic nonasthmatic controls (NC). 10570327 1999
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.340 AlteredExpression disease BEFREE Immunoreactivity and transcripts of eotaxin and CCR3 were significantly increased in lesional skin from atopic dermatitis, but not in nonatopic controls. 10417617 1999
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.320 GeneticVariation group BEFREE Further study will be of interest to test whether CCR3-C218S variation or any of the CCR4 variations has a significant role in rendering susceptibility to immunological diseases or resistance to HIV infection. 11196669 1999
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.320 Biomarker group CTD_human Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy. 10202824 1999
CUI: C4505456
Disease: HIV Coinfection
HIV Coinfection 		0.300 Biomarker disease CTD_human Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy. 10202824 1999
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.130 GeneticVariation group BEFREE In this study, variation screening of the entire coding regions of CCR3 and CCR4 was performed, and possible association with several autoimmune diseases was tested, using the genomic DNA from 304 Japanese healthy individuals and 272 Japanese patients with rheumatic diseases. 11196669 1999
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.120 Biomarker disease BEFREE Reactivity of eosinophils to the monoclonal antibody against CCR3 and the chemotaxis to eotaxin were slightly reduced in this patient as compared with healthy controls or a patient with Behçet disease homozygous for the common allele, while CCR3 mRNA level was not different. 11196669 1999
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases 		0.110 GeneticVariation group BEFREE Further study will be of interest to test whether CCR3-C218S variation or any of the CCR4 variations has a significant role in rendering susceptibility to immunological diseases or resistance to HIV infection. 11196669 1999
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.070 Biomarker disease BEFREE Repeated anti-CCR3 mAb treatment in these mice significantly reduced tissue eosinophilia in the lung tissue and bronchoalveolar lavage fluid. 10380909 1999
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.070 Biomarker disease BEFREE These findings suggest that multiple C-C chemokines, acting at least in part via CCR3, contribute to bronchial eosinophilia in both atopic and nonatopic asthma. 10570327 1999
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.060 Biomarker group BEFREE Repeated anti-CCR3 mAb treatment in these mice significantly reduced tissue eosinophilia in the lung tissue and bronchoalveolar lavage fluid. 10380909 1999
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.060 Biomarker group BEFREE These findings suggest that multiple C-C chemokines, acting at least in part via CCR3, contribute to bronchial eosinophilia in both atopic and nonatopic asthma. 10570327 1999
CUI: C0013595
Disease: Eczema
Eczema 		0.040 AlteredExpression disease BEFREE Immunoreactivity and transcripts of eotaxin and CCR3 were significantly increased in lesional skin from atopic dermatitis, but not in nonatopic controls. 10417617 1999
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.020 Biomarker disease BEFREE Together, these findings suggested an important role for CCR3-binding chemokines in eosinophil recruitment to nasal polyps. 10415058 1999
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 Biomarker disease BEFREE The purpose of this study was to enumerate CD34(+) cell numbers in blood and bone marrow from atopic asthmatics and control subjects and to test the hypothesis that there is an increased bone marrow pool of CCR3(+) eosinophils in patients with atopic asthma, as compared with control subjects. 9893192 1999