Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.330 Biomarker disease BEFREE Organic solute transporter-β (SLC51B) deficiency in two brothers with congenital diarrhea and features of cholestasis. 28898457 2018
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.330 Biomarker disease BEFREE In this article, we review the potential clinical implications of the major BS transporters BSEP, OSTα/OSTβ and NTCP in the pathogenesis of hereditary and acquired cholestatic syndromes, provide an overview on transcriptional control of these transporters by the key regulatory nuclear receptors and discuss the potential therapeutic role of novel transcriptional activators of BS transporters in cholestasis. 24333169 2014
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.330 Biomarker disease CTD_human Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. 22461449 2012
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.330 Biomarker disease CTD_human Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. 16423920 2006
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.330 AlteredExpression disease LHGDN Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. 16423920 2006
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.300 Biomarker group CTD_human Diabetic cognitive dysfunction is associated with increased bile acids in liver and activation of bile acid signaling in intestine. 29382564 2018
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus 		0.300 Biomarker group CTD_human Diabetic cognitive dysfunction is associated with increased bile acids in liver and activation of bile acid signaling in intestine. 29382564 2018
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.300 Biomarker disease CTD_human Hepatic OSTalpha and OSTbeta mRNA increased 3- and 32-fold, respectively, in patients with PBC compared with controls, whereas expression of Ostalpha and Ostbeta also increased in the liver of rats and mice following CBDL. 16423920 2006
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.300 Biomarker disease CTD_human Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. 16423920 2006
CUI: C0238065
Disease: Secondary Biliary Cholangitis
Secondary Biliary Cholangitis 		0.300 Biomarker disease CTD_human Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. 16423920 2006
CUI: C4551595
Disease: Biliary Cirrhosis, Primary, 1
Biliary Cirrhosis, Primary, 1 		0.300 Biomarker disease CTD_human Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. 16423920 2006
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.010 Biomarker phenotype BEFREE Organic solute transporter-β (SLC51B) deficiency in two brothers with congenital diarrhea and features of cholestasis. 28898457 2018
CUI: C0401151
Disease: Chronic diarrhea
Chronic diarrhea 		0.010 Biomarker disease BEFREE The findings identify OSTβ deficiency as a cause of congenital chronic diarrhea with features of cholestatic liver disease. 28898457 2018
CUI: C0860204
Disease: Cholestatic liver disease
Cholestatic liver disease 		0.010 Biomarker disease BEFREE The findings identify OSTβ deficiency as a cause of congenital chronic diarrhea with features of cholestatic liver disease. 28898457 2018
CUI: C0008350
Disease: Cholelithiasis
Cholelithiasis 		0.010 AlteredExpression disease BEFREE The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers compared with controls. 18469300 2008
CUI: C0947622
Disease: Cholecystolithiasis
Cholecystolithiasis 		0.010 AlteredExpression disease BEFREE The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers compared with controls. 18469300 2008