CCR4, C-C motif chemokine receptor 4, 1233

N. diseases: 168; N. variants: 1
Disease: Exanthema ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015230
Disease: Exanthema
Exanthema 		0.030 GeneticVariation phenotype BEFREE It is possible that the efficacy of mogamulizumab could be established by the occurrence of skin rashes and/or CCR4 mutational status. 30981611 2019
CUI: C0015230
Disease: Exanthema
Exanthema 		0.030 AlteredExpression phenotype BEFREE Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed to depletion of CCR4<sup>+</sup> regulatory T cells. 29399406 2018
CUI: C0015230
Disease: Exanthema
Exanthema 		0.030 Biomarker phenotype BEFREE Up-regulation of CCL17, CCL22 and CCR4 in drug-induced maculopapular exanthema. 17456218 2007