|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCR4 blockade inhibited tumor growth and Treg infiltration into the tissues in a xenograft mouse model.
|
31160277 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T<sub>reg</sub> Trafficking into the Tumor Microenvironment.
|
31259550 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CCR4 expression was observed in 64.2% of patients with TSCC and showed a significant association with tumor stage (P = .037).
|
30395826 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival.
|
30907146 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Lymph node egress of tumor-activated Tregs was required for their C-C chemokine receptor 4 (Ccr4)-dependent homing to nascent tumor sites.
|
30026331 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCR4 Antagonists Inhibit T<sub>reg</sub> Trafficking into the Tumor Microenvironment.
|
30344896 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, our data establish a critical role for Not3 and the entire CCR4-NOT complex as tumor suppressor.
|
30144809 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, we have developed a diphtheria toxin-based recombinant anti-human CCR4 immunotoxin for targeting CCR4<sup>+</sup> tumors and Tregs.
|
29873181 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that high CCR4 expression in the tumor microenvironment would be associated with a poor prognosis and would act as a biomarker in lung adenocarcinoma.
|
30233846 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, we found that the expression of CCR4 is significantly higher in paired clinical specimens of melanoma metastases than in samples of primary tumors from the same patients.
|
28415693 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we initially demonstrated that CCR4 is overexpressed in HCC specimens, and its elevation in HCC tissues positively correlates with tumor capsule breakthrough and vascular invasion.
|
28959024 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HPV197 E6 also binds and inhibits the TP53 tumor suppressor and interacts with the CCR4-NOT ubiquitin ligase and deadenylation complex.
|
27771561 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In spite of prominent changes in the myeloid compartment, the anti-CCR4 antibody did not affect RENCA tumors in T cell-deficient mice, and treatment with an anti-class II MHC antibody abrogated its antitumor activity.
|
28134623 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCR4 was correlated with tumor aggressive behavior in ccRCC.
|
24554520 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results show clear-cut mRNA levels and surface expression of CCR4 on a colon cancer cell line (HT-29) and on tumor cells (AZ-97).
|
23649168 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer.
|
21479551 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCR4 antagonist represents a competitive class of Treg inhibitor able to induce functional anti-self CD8(+) T cells and tumor growth inhibition when combined with vaccines.
|
21908423 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the CCR4 ligand CCL22 is secreted by glioblastomas and may explain the specific Treg accumulation seen in these tumors.
|
20537408 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, T lymphocytes expressing both CCR4 and a chimeric antigen receptor directed to the HL associated antigen CD30 sustain their cytotoxic function and cytokine secretion in vitro, and produce enhanced tumor control when infused intravenously in mice engrafted with human HL.
|
19377047 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
|
17641067 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A significant correlation was found between mRNA expression of CCR4 and FoxP3, suggesting a possible association of CCR4-positive tumors with Treg cells and thereby with an immunocompromised state.
|
15328188 |
2004 |