CNTF, ciliary neurotrophic factor, 1270

N. diseases: 114; N. variants: 3
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 Biomarker disease BEFREE These developments may prove to be a breakthrough for therapeutic applications of systemically administered CNTF in pathologies such as multiple sclerosis or Alzheimer's disease. 26187860 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 Biomarker disease BEFREE Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). 26399250 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 AlteredExpression disease BEFREE Up-regulation of ciliary neurotrophic factor in astrocytes by aspirin: implications for remyelination in multiple sclerosis. 23653362 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 Biomarker disease BEFREE Recent studies in new EAE models, especially in transgenic ones, have in connection with new analytical techniques such as microarray assays provided a deeper insight into the pathogenic cellular and molecular mechanisms of EAE and potentially of MS. For example, it was possible to better delineate the role of soluble pro-inflammatory (tumor necrosis factor-α, interferon-γ and interleukins 1, 12 and 23), anti-inflammatory (transforming growth factor-β and interleukins 4, 10, 27 and 35) and neurotrophic factors (ciliary neurotrophic factor and brain-derived neurotrophic factor). 20558237 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 Biomarker disease BEFREE CNTF-receptor complex members, CNTFRalpha, LIFRbeta and GP130, were increased in MS cortical neurons. 17898009 2007
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease LHGDN Similar genotype frequencies for the CNTF mutation were obtained in MS patients (genotype 0101=74.8%, 0102=22.3%, 0202=2.9%) and controls (genotype 0101=71.7%, 0102=26.5%, 0202=1.8%) even after stratification for the HLA-DRB1*15 allele. 11857064 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease BEFREE Similar genotype frequencies for the CNTF mutation were obtained in MS patients (genotype 0101=74.8%, 0102=22.3%, 0202=2.9%) and controls (genotype 0101=71.7%, 0102=26.5%, 0202=1.8%) even after stratification for the HLA-DRB1*15 allele. 11857064 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease BEFREE We screened 288 unselected patients with multiple sclerosis (MS) (mean age, 40.2 +/- 10.2 years; range, 18-71 years) for a previously described homozygous null mutation within the CNTF gene leading to a truncated, biologically inactive protein. 11890844 2002
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.070 GeneticVariation disease LHGDN We screened 288 unselected patients with multiple sclerosis (MS) (mean age, 40.2 +/- 10.2 years; range, 18-71 years) for a previously described homozygous null mutation within the CNTF gene leading to a truncated, biologically inactive protein. 11890844 2002