|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
<i>AC092159.2</i> may be an important regulator of TMEM18, which is an important susceptibility gene related to obesity and type 2 diabetes.
|
31361511 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.340 |
Biomarker
|
disease |
BEFREE |
<i>AC092159.2</i> may be an important regulator of TMEM18, which is an important susceptibility gene related to obesity and type 2 diabetes.
|
31361511 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein.
|
21980424 |
2011 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells.
|
18559506 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transmembrane protein 18 (Tmem18) is an obesity-associated gene essential for adipogenesis; however, its function in the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) is still unclear.
|
31288024 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
BACKGROUND This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents.
|
30341978 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Eight loci, rs10968576 (BDNF), rs3817334 (MTCH2), rs1558902 (FTO), rs571312 (MC4R), rs543874 (SEC16B), rs987237 (TFAP2B), rs2867125 (TMEM18) and rs7138803 (FAIM2), were previously known obesity susceptibility loci, and the remaining four loci, rs1514175 (TNNI3K), rs206936 (NUDT3), rs4771122 (MTIF3) and rs2241423 (MAP2K5), were newly identified as BMI loci by the GIANT study.
|
22041983 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, we genotyped 502 severely obese and 527 healthy Swedish children for two SNPs near TMEM18 (rs6548238 and rs756131).
|
20380707 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study.
|
20628085 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.340 |
Biomarker
|
disease |
CTD_human |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, we confirmed three previously reported obesity susceptibility loci: 16q12 [rs62033400, P = 1.97 × 10(-14), FTO (fat mass and obesity associated)], 18q22 [rs6567160, P = 8.09 × 10(-19), MC4R (melanocortin 4 receptor)] and 2p25 [rs939583, P = 1.07 × 10(-7), TMEM18 (transmembrane protein 18)].
|
24064335 |
2014 |
|
Pediatric Obesity
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In summary, moderately rare missense variants within the FTO, MC4R, and TMEM18 genes observed in our study did not confer risk of common childhood obesity in African Americans except for a degree of evidence for one known loss-of-function variant in MC4R.
|
23505181 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the meta-analysis of 42 studies for 11 obesity/BMI-associated loci, we observed a statistically significant association of the FTO rs9939609 polymorphism (66 425 T2D cases/239 689 normoglycaemic subjects; P = 1·00 × 10(-41) ) and six other variants with T2D risk (17 915 T2D cases/27 531 normoglycaemic individuals: n = 40 629-130 001; all P < 0·001 for SH2B1 rs7498665, FAIM2 rs7138803, TMEM18 rs7561317, GNPDA2 rs10938397, BDNF rs925946 and NEGR1 rs2568958).
|
24528214 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this multi-analytical approach, FTO rs9939609 and IRX3 rs3751723, along with TCF7L2 rs7903146 and TMEM18 rs6548238, emerged as the major SNPs contributing to BMI linked obesity risk in the North Indian population.
|
27650258 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Kaplan-Meier survival analysis revealed that TMEM18 overexpression was associated with a better AML prognosis with good discrimination (p = 0.019).
|
30199869 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related genetic variants, including TMEM18 (rs6548238), SH2B1 (rs7498665), and GNPDA2 (rs10938397), have been shown to be associated with obesity in the general population.
|
26263223 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our results add to the evidence that BMI related variants in and near FTO and TMEM18 may increase the risk for T2D not only through secondary effects of obesity.
|
23860325 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results add to the evidence that BMI related variants in and near FTO and TMEM18 may increase the risk for T2D not only through secondary effects of obesity.
|
23860325 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that TMEM18 affects substrate levels through insulin and glucagon signaling, and its downregulation induces a metabolic state resembling type 2 diabetes.
|
27029472 |
2016 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of TMEM18 was seen in the current study to provide NSCs and neural precursors an increased migration capacity toward glioblastoma cells in vitro and in the rat brain.
|
18559506 |
2008 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of TMEM18 was seen in the current study to provide NSCs and neural precursors an increased migration capacity toward glioblastoma cells in vitro and in the rat brain.
|
18559506 |
2008 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of TMEM18 was seen in the current study to provide NSCs and neural precursors an increased migration capacity toward glioblastoma cells in vitro and in the rat brain.
|
18559506 |
2008 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of TMEM18 was seen in the current study to provide NSCs and neural precursors an increased migration capacity toward glioblastoma cells in vitro and in the rat brain.
|
18559506 |
2008 |
|
Diabetes
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes.
|
23860325 |
2013 |
|
Diabetes Mellitus
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes.
|
23860325 |
2013 |