|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single SNP analysis showed that genetic variants in SLC30A10, TMEM18, GNPDA2, PRL, TFAP2B, BDNF, MTCH2, FTO, and MC4R were nominally associated with waist circumference (WC), BMI, and risk for abdominal or general obesity in the untreated patients with type 2 diabetes, as well as in the total group of patients with type 2 diabetes (untreated and treated) (p < 0.05).
|
31167208 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Single SNP analysis showed that genetic variants in SLC30A10, TMEM18, GNPDA2, PRL, TFAP2B, BDNF, MTCH2, FTO, and MC4R were nominally associated with waist circumference (WC), BMI, and risk for abdominal or general obesity in the untreated patients with type 2 diabetes, as well as in the total group of patients with type 2 diabetes (untreated and treated) (p < 0.05).
|
31167208 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|
19079261 |
2009 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
SNPs mapping to 12 BMI-associated loci which have been extensively replicated across different ethnicities, i.e., BDNF, FAIM2, ETV5, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18, were studied in association with PCOS within each cohort using the additive genetic model followed by a combined analysis.
|
24498077 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to investigate whether the genetic risk score (GRS) based on previously associated obesity polymorphisms (SNP) rs9939609 (fat mass and obesity-associated (FTO)), rs6548238 (transmembrane protein 18 (TMEM18)) and rs16835198 (fibronectin type III domain containing 5 (FNDC5)) could serve as a predictor for anthropometric characteristics in a sample of Brazilian children and adolescents.
|
30311592 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The exons of FTO, MC4R, and TMEM18 in an initial subset of our cohort were sequenced, that is, 200 obese (BMI ≥ 95 th percentile) and 200 lean AA children (BMI ≤ 5 th percentile).
|
23505181 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The observed association between variants in/near FTO, MC4R, MTCH2, TFAP2B, SEC16B and TMEM18 with change in BMI from adolescence to young adulthood suggest that the genetic effect of BMI loci varies over time in a complex manner, highlighting the importance of investigating loci influencing obesity risk across the life course.
|
28025578 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results revealed a significant association of the TMEM18 rs7561317 with overweight/obese phenotype in more than one genetic model.
|
31628562 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The SNP rs10913469 in SEC16B (P=0.000012) and four SNPs (rs2867125, rs6548238, rs4854344 and rs7561317) in the TMEM18 gene (P=0.00015), all of which were in almost absolute linkage disequilibrium, were significantly associated with obesity in the Japanese population.
|
19851340 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1.
|
21796137 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data support the original finding that there is an association between measures of obesity and a variant near the MC4R gene and extends these results to a younger population and implicates FTO, TMEM18, and SH2B1 polymorphisms in subcutaneous fat regulation.
|
20725061 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This report highlights the influence of TMEM18 in Mexican-Mestizo children obesity, while adipokine and cytokine polymorphisms were not associated with it.
|
31354816 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aims to test whether 10 polymorphisms in obesity-related genes methionine sulfoxide reductase A (MSRA), transcription factor AP-2 beta (TFAP2B), melanocortin 4 receptor (MC4R), neurexin 3 (NRXN3), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), transmembrane protein 18 (TMEM18), homolog of S. cerevisiae Sec16 (SEC16B), homeobox B5 (HOXB5) and olfactomedin 4 (OLFM4) are associated with the risk of obesity in Portuguese children.
|
24670271 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This work is the first to experimentally describe the metabolic consequences of TMEM18 knockdown, and further supports its association with obesity.
|
27029472 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using lncRNA microarray, we found lncRNA AC092159.2 was highly expressed in differentiated HPA-v and located ~247 bp upstream of the TMEM18, which was associated with BMI and obesity.
|
30753134 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variants of TMEM18 and FTO are associated with obesity indices during puberty in Chinese children, but candidate SNPs of NEGR1, GNPDA2, MTCH2, SH2B1, MC4R and KCTD15 have no significant effects on obesity indices.
|
22083549 |
2012 |
|
Pediatric Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that TMEM18 is involved in both adult and childhood obesity.
|
20380707 |
2010 |
|
Metabolic Syndrome X
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found single-nucleotide polymorphism data, suggesting that TMEM18 may be involved in the regulation/physiology of metabolic syndrome based on associations with insulin, homeostatic model assessment-β (HOMAβ), triglycerides, and blood sugar.
|
27029472 |
2016 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 85,437 individuals aged 20-100 years from the Copenhagen General Population Study for FTO (rs9939609), MC4R (rs17782313), TMEM18 (rs6548238) GNPDA2 (rs10938397) and BDNF (rs10767664); 14,500 individuals experienced wheezing and 5406 had asthma.
|
26504195 |
2016 |
|
Wheezing
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We genotyped 85,437 individuals aged 20-100 years from the Copenhagen General Population Study for FTO (rs9939609), MC4R (rs17782313), TMEM18 (rs6548238) GNPDA2 (rs10938397) and BDNF (rs10767664); 14,500 individuals experienced wheezing and 5406 had asthma.
|
26504195 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped obesity risk single nucleotide polymorphisms (SNPs) derived from genome-wide association studies in or in proximity to the following genes: NEGR1, TNKS, SDCCAG8, FTO, MC4R, TMEM18, PTER, MTCH2, SH2B1, MAF, NPC1, and KCTD15.
|
23843577 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We nominally replicated the association with obesity (BMI ≥30 kg/m(2)) of six SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 loci (1.28 ≤ odds ratio (OR) ≤ 1.35; 0.004 ≤ P ≤ 0.043).
|
21720444 |
2012 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We sequenced TMEM18 and regions downstream of TMEM18 on chromosome 2 in 3976 individuals of European ancestry from 3 community-based cohorts (Atherosclerosis Risk in Communities, Cardiovascular Health Study, and Framingham Heart Study), including 200 adults selected for high BMI.
|
24951660 |
2014 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We sequenced TMEM18 and regions downstream of TMEM18 on chromosome 2 in 3976 individuals of European ancestry from 3 community-based cohorts (Atherosclerosis Risk in Communities, Cardiovascular Health Study, and Framingham Heart Study), including 200 adults selected for high BMI.
|
24951660 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |