Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genotype data of the 8 PACG single-nucleotide polymorphisms (SNPs) (rs11024102 at PLEKHA7, rs3753841 at COL11A1, rs1015213 located between PCMTD1 and ST18 on Chromosome 8q, rs3816415 at EPDR1, rs1258267 at CHAT, rs736893 at GLIS3, rs7494379 at FERMT2, and rs3739821 mapping in between DPM2 and FAM102A) were available.
|
31377279 |
2019 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three of the 12 SNPs in COL11A1, rs1676486 (<i>P</i>=0.026, OR = 2.089, 95% CI = 1.092-3.996), rs3753841 (<i>P</i>=0.036, OR = 1.886, 95% CI = 1.038-3.426), and rs12138977 (<i>P</i>=0.024, OR = 2.133, 95% CI = 1.104-4.123) were found to have a significant association with PACG.
|
30809385 |
2019 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The SNP rs3753841 in COL11A1, rs1258267 in CHAT and rs736893 in GLIS3 are associated with PACG in northern Chinese people, and the association of genetic markers manifests a tendency of ethnic diversity.
|
30399154 |
2018 |
Angle Closure Glaucoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.
|
27064256 |
2016 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We affirmed the association of PACG and combined PACS/PAC/PACG with 10 polymorphisms in 8 genes/loci, including COL11A1 (rs3753841-G, OR, 1.22; P = 0.00046), HGF (rs17427817-C, OR, 2.02; P = 6.9E-07; rs5745718-A, OR, 2.11; P = 9.9E-07), HSP70 (rs1043618, GG+GC, OR, 0.52; P = 0.0010), MFRP (rs2510143-C, OR, 0.66; P = 0.012; rs3814762-G, OR, 1.40; P = 0.0090), MMP9 (rs3918249-C, OR, 1.35; P = 0.034), NOS3 (rs7830-A, OR, 0.80; P = 0.036), PLEKHA7 (rs11024102-G, OR, 1.24; P = 8.3E-05), and PCMTD1-ST18 (rs1015213-A, OR, 1.59; P = 0.00013).
|
26854036 |
2016 |
Angle Closure Glaucoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.
|
27064256 |
2016 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies revealed a large number of susceptibility gene variants associated with both POAG (e.g., CDKN2BAS, CAV1/CAV2, and ATOH7) and PACG (e.g., PLEKHA7 and COL11A1 PCMTD1-ST18).
|
26497787 |
2015 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic associations in PLEKHA7 and COL11A1 with primary angle closure glaucoma: a meta-analysis.
|
25732101 |
2015 |
Angle Closure Glaucoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both COL11A1 and PLEKHA7 were shown to confer significant risk for acute PAC/PACG.
|
24854855 |
2014 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, three genetic susceptibility loci for primary angle closure glaucoma (PACG) were identified: COL11A1 rs3753841, PCMTD1-ST18 rs1015213, and PLEKHA7 rs11024102.
|
24474268 |
2014 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three loci defined by single nucleotide polymorphisms (SNPs) rs11024102 in PLEKHA7, rs3753841 in COL11A1, and rs1015213 between the PCMTD1 and ST18 genes, recently have been associated with primary angle closure glaucoma (PACG).
|
23847314 |
2013 |
Angle Closure Glaucoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three susceptibility loci for primary angle-closure glaucoma (PACG) were recently identified: PLEKHA7 rs11024102, COL11A1 rs3753841, and rs1015213 located in the intergenic region between PCMTD1 and ST18.
|
23920366 |
2013 |
Angle Closure Glaucoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
|
22922875 |
2012 |