|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur, including mood disorders, schizophrenia, obsessive compulsive disorder, alcohol and substance abuse, and attention deficit hyperactivity disorder.
|
8807664 |
1996 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
CTD_human |
These provisional findings suggest that newly developed COMT inhibitors such as tolcapone, applied in Parkinson's disease, might in due time be considered in the treatment of ADHD.
|
10490706 |
1999 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
These provisional findings suggest that newly developed COMT inhibitors such as tolcapone, applied in Parkinson's disease, might in due time be considered in the treatment of ADHD.
|
10490706 |
1999 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Linkage study of catechol-O-methyltransferase and attention-deficit hyperactivity disorder.
|
10581494 |
1999 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The absence of association between COMT alleles and ADHD indicated that this locus does not play a significant role or at least a role independent of other genes, in predisposing to ADHD in the Irish population.
|
10898900 |
2000 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Failure to replicate an association between the catechol-O-methyltransferase polymorphism and attention deficit hyperactivity disorder in a second, independently recruited Israeli cohort.
|
11121197 |
2000 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HHRR analysis suggested that the low enzyme-activity COMT Met allele was preferentially transmitted to ADHD boys (160 trios, chi(2) = 3.858, P = 0.05, df = 1) but not girls.
|
12627475 |
2003 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Contrary to the observed association between WCST performance and the Val108/158 Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD.
|
15613245 |
2004 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, a functional Val158Met polymorphism in COMT that alters the activity of the encoded protein has been strongly implicated in frontal lobe function, with the high activity Valine allele being associated with poorer performance, and ADHD is thought to involve fronto-striatal pathways.
|
15635644 |
2005 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder.
|
16275815 |
2005 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After pooling the results, no significant association between the COMT Vall58/108Met polymorphism and ADHD was found (OR 0.99 (95% CI: 0.88-1.12), P = 0.87).
|
16676224 |
2006 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome.
|
16734939 |
2007 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Schizophrenia and Attention Deficit Hyperactivity Disorder, which lead to failure of attentional modulation and working memory, introduce significant changes in gamma responses and have significant associations with genetic polymorphisms of dopamine receptor D4 (DRD4), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT).
|
16751296 |
2007 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Sleep and COMT polymorphism in ADHD children: preliminary actigraphic data.
|
16865041 |
2006 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings are consistent with evidence of overlap between schizophrenia and ADHD and support an involvement of COMT genotype in ADHD features.
|
17109713 |
2006 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Contrasting findings for COMT and DAT-1 may best be considered in terms of prediction of medication response in ADHD in the case of COMT, but in aetiological terms in the case of DAT-1, which is abundant in the striatum and possibly plays a greater role in determining hyperactivity and impulsivity, than working memory deficiencies.
|
17464676 |
2007 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 48 base pair (bp) repeat, DRD4 120 bp duplicated repeat, SLC6A3 (DAT1) 40 bp variable number of tandem repeats (VNTR), and COMT Val158Met).
|
17886261 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A haplotype composed of three SNPs [rs2097603; rs4680 (158Val/Met); rs165599] representing the major linkage disequilibrium blocks in COMT and previously implicated in functional variation, was found to be associated with ADHD and OCD in 22q11.2DS individuals.
|
17949513 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We did not find main effects of the COMT and SLC6A2 NET1 gene haplotypes on any ADHD symptom severity score.
|
17994190 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Three main outcomes were obtained: (1) adverse events showed a small but positive correlation with current ADHD severity; (2) NET, COMT and the A/G variant within SERTPR were not associated with ADHD severity; (3) taking into account stressors, the long (L) SERTPR variant showed a mild effect on ADHD, being associated with an increased severity, particularly as regard affective dysregulations; on the other hand, in subjects exposed to early stressors, it showed a protective effect, as compared to the short (S) variant.
|
18214863 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children.
|
18214865 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To test if variations in the catechol O-methyltransferase gene (COMT) would prove useful in identifying the subset of children with ADHD who exhibit antisocial behavior.
|
18250258 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to examine the association of the COMT Val(108/158)Met polymorphism with (1) task-oriented behavior in children with ADHD, and (2) response of this behavior given methylphenidate (MPH) treatment.
|
18580877 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide evidence of an association between the COMT genotype and MPH response as assessed by the teachers of children with ADHD.
|
18703939 |
2008 |