COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Pain, Postoperative ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE COMT and OPRM1 were the most identified genetic polymorphisms associated with postoperative pain intensity. 31080143 2019
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE Recent genetic studies have reported associations of genetic variants in catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), voltage-gated channel alpha subunit 11 (SCN11A) and μ-opioid receptor (OPRM1) genes with postoperative pain. 29994939 2018
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain. 27792797 2017
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE For postoperative pain, a significant interaction was found between OPRM1 and the low pain sensitivity (LPS; GCGG) haplotype of COMT ( p = .017). 27903758 2017
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy. 25963335 2016
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain. 25185591 2014
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE The associations of four COMT SNPs (rs6269, rs4633, rs4818 and rs4680) with postoperative pain were analyzed and outcome measures included maximum pain scores, need for postoperative opioid interventions and postoperative morphine requirements. 24533707 2014
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE By considering COMT, OPRM1, and UGT2B7 genotypes, as well as pharmacokinetic results, only COMT polymorphisms appear to be predictive of morphine need in postoperative pain therapy. 23686330 2013
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 GeneticVariation phenotype BEFREE The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation. 22718527 2013
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 AlteredExpression phenotype BEFREE In human studies, low COMT (catechol-O-methyltransferase) activity has been associated with increased sensitivity to acute clinical preoperative or postoperative pain. 22722321 2012
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 AlteredExpression phenotype BEFREE In human pain studies, a low COMT activity is often associated with increased pain sensitivity in experimental pain models and with increased pre- and postoperative pain in acute clinical situations. 21095465 2010
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative 		0.100 Biomarker phenotype BEFREE Variations in the catecholamine metabolizing enzyme genes (MAOA and COMT) showed significant associations with the maximum post-operative pain rating while the serotonin transporter gene (SLC6A4) showed association with the onset time of post-operative pain. 16848906 2006