|
Mental Depression
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40 mg/kg, s.c.) or vehicle (Oil) for 21 days prior to conception) to investigate the effects of sertraline (a frequently prescribed SSRI; 20 mg/kg p.o., treatment started ∼7 days prior to conception) and its discontinuation during pregnancy (on gestational day 16) compared to vehicle (water) treatment on the development of the offspring.
|
30836156 |
2019 |
|
Depressive disorder
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40 mg/kg, s.c.) or vehicle (Oil) for 21 days prior to conception) to investigate the effects of sertraline (a frequently prescribed SSRI; 20 mg/kg p.o., treatment started ∼7 days prior to conception) and its discontinuation during pregnancy (on gestational day 16) compared to vehicle (water) treatment on the development of the offspring.
|
30836156 |
2019 |
|
Depressed mood
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40 mg/kg, s.c.) or vehicle (Oil) for 21 days prior to conception) to investigate the effects of sertraline (a frequently prescribed SSRI; 20 mg/kg p.o., treatment started ∼7 days prior to conception) and its discontinuation during pregnancy (on gestational day 16) compared to vehicle (water) treatment on the development of the offspring.
|
30836156 |
2019 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we tested the behavioral effects of CST-14 in the in a variety of classical rodent models of depression [forced swimming test (FST), tail suspension test (TST) and novelty-suppressed feeding test].
|
30072893 |
2018 |
|
Depressive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we tested the behavioral effects of CST-14 in the in a variety of classical rodent models of depression [forced swimming test (FST), tail suspension test (TST) and novelty-suppressed feeding test].
|
30072893 |
2018 |
|
Depressed mood
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Here, we tested the behavioral effects of CST-14 in the in a variety of classical rodent models of depression [forced swimming test (FST), tail suspension test (TST) and novelty-suppressed feeding test].
|
30072893 |
2018 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings provide the first evidence indicating that Rg1 can alleviate CORT-induced gap junction dysfunction, which may have clinical significance in the treatment of depression.
|
28642095 |
2017 |
|
Depressive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings provide the first evidence indicating that Rg1 can alleviate CORT-induced gap junction dysfunction, which may have clinical significance in the treatment of depression.
|
28642095 |
2017 |
|
Depressed mood
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These findings provide the first evidence indicating that Rg1 can alleviate CORT-induced gap junction dysfunction, which may have clinical significance in the treatment of depression.
|
28642095 |
2017 |
|
Diabetic Retinopathy
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Serum cortistatin levels were not statistically significant between diabetic patients with and without diabetic retinopathy and healthy control subjects (<i>p</i> = 0.166).
|
31822132 |
2019 |
|
Colitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In vivo, the expression of CST-14 mRNA was significantly decreased in the colon of colitis mice and CST-14 significantly inhibited GI transit rate in colitis mice, and delayed the emergence of liquid feces in castor oil-induced diarrhea mouse model.
|
29477944 |
2018 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Besides its action in locomotor activity and sleep, cortistatin inhibits inflammation in different experimental models of autoimmune diseases.
|
27922195 |
2017 |
|
Autoimmune Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Cortistatin is a neuropeptide expressed in the vascular system and atherosclerotic plaques that regulates vascular calcification and neointimal formation, and inhibits inflammation in different experimental models of autoimmune diseases.
|
28406244 |
2017 |
|
Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on these interesting results, we wanted to better investigate which cellular actors could be involved in the protection of CORT-nursed rats from TNBS-induced experimental colitis.
|
28267767 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We previously demonstrated that Mediator kinase inhibitor cortistatin A (CA) reduced proliferation of JAK2-mutant AML in vitro and in vivo and also suppressed CDK8-dependent phosphorylation of STAT1 at serine 727.
|
29239838 |
2017 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Samples from 46 patients were processed to isolate mRNA from tumor and adjacent non-tumor region, and the expression levels of SST/CORT and ghrelin systems components, determined by quantitative-PCR, were compared to those of 7 normal lung tissues.
|
28577942 |
2017 |
|
Vascular calcification
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Cortistatin is a neuropeptide expressed in the vascular system and atherosclerotic plaques that regulates vascular calcification and neointimal formation, and inhibits inflammation in different experimental models of autoimmune diseases.
|
28406244 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We report that the natural product cortistatin A (CA) selectively inhibits Mediator kinases, has anti-leukaemic activity in vitro and in vivo, and disproportionately induces upregulation of SE-associated genes in CA-sensitive AML cell lines but not in CA-insensitive cell lines.
|
26416749 |
2015 |
|
Vascular calcification
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Cortistatin is elevated in plasma of patients experiencing coronary heart disease and attenuates vascular calcification.
|
23595952 |
2013 |
|
Diabetic Retinopathy
|
0.020 |
Biomarker
|
disease |
LHGDN |
Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects.
|
16043736 |
2005 |
|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors.
|
10894940 |
2000 |
|
Gestational Diabetes
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Conclusion:</b> Cortistatin levels were significantly lower in GDM pregnancies and related to serum insulin and glucose levels and HOMA-IR in pregnancy.
|
31154879 |
2020 |
|
Asthma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Differential DNA methylation of IL12B and CORT are associated with inhaled corticosteroid treatment response in persistent childhood asthmatics.
|
31187518 |
2019 |
|
Behcet Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum Cortistatin Levels in Patients with Ocular Active and Ocular Inactive Behçet Disease.
|
31314641 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Cortistatin (CST), a newly discovered biological peptide, has been acknowledged for its protective effects against cardiovascular diseases.
|
31807542 |
2019 |