TAAR1, trace amine associated receptor 1, 134864

N. diseases: 51; N. variants: 4
Disease: Cataplexy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007384
Disease: Cataplexy
Cataplexy 		0.020 Biomarker disease BEFREE TAAR1 agonism also increases wakefulness and suppresses rapid-eye movement (REM) sleep in mice and rats and reduces cataplexy in two mouse models of narcolepsy. 30954024 2019
CUI: C0007384
Disease: Cataplexy
Cataplexy 		0.020 Biomarker disease BEFREE Both TAAR1 compounds also mitigated cataplexy, the pathognomonic symptom of this disorder, in the narcolepsy models. 27919403 2017