ADORA2A, adenosine A2a receptor, 135

N. diseases: 213; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020649
Disease: Hypotension
Hypotension 		0.300 Biomarker phenotype CTD_human Adenosine release in morphine-induced hypotension in rats. 1592228 1992
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease BEFREE Human adenosine A2a receptor (A2aAR) gene: systematic mutation screening in patients with schizophrenia. 9029412 1996
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.370 GeneticVariation disease BEFREE Mapping of the human adenosine A2a receptor gene: relationship to potential schizophrenia loci on chromosome 22q and exclusion from the CATCH 22 region. 9050917 1997
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.020 Biomarker group BEFREE Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. 9262401 1997
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.020 GeneticVariation disease BEFREE Thus, the alleles detected by this RFLP polymorphism in the A2aAR gene are not associated with essential hypertension. 9880133 1998
CUI: C0027092
Disease: Myopia
Myopia 		0.210 Biomarker disease MGD A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. 10531422 1999
CUI: C0027092
Disease: Myopia
Myopia 		0.210 Biomarker disease MGD Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors. 10771351 2000
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.390 Biomarker group CTD_human Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 12825092 2003
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.370 Biomarker disease CTD_human Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 12825092 2003
CUI: C0086769
Disease: Panic Attacks
Panic Attacks 		0.310 Biomarker disease CTD_human Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 12825092 2003
CUI: C0376280
Disease: Anxiety States, Neurotic
Anxiety States, Neurotic 		0.300 Biomarker disease CTD_human Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 12825092 2003
CUI: C1279420
Disease: Anxiety neurosis (finding)
Anxiety neurosis (finding) 		0.300 Biomarker disease CTD_human Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 12825092 2003
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 Biomarker disease BEFREE Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease. 14663020 2003
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.370 Biomarker disease BEFREE We have undertaken an analysis of several DNA sequence variations in the adenosine 2A receptor (ADORA2A) in a large sample of panic disorder pedigrees. 14666117 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.370 GeneticVariation disease LHGDN Individuals from 70 panic disorder pedigrees, and 83 child-parent 'trios', were genotyped at five single-nucleotide polymorphisms (SNPs) in and near the ADORA2A gene and were analyzed for genetic linkage and association. 14666117 2004
CUI: C0013221
Disease: Drug toxicity
Drug toxicity 		0.300 Biomarker group CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0020649
Disease: Hypotension
Hypotension 		0.300 Biomarker phenotype CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Enhanced morphine withdrawal and micro -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice. 14756803 2004
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug 		0.300 Biomarker group CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Enhanced morphine withdrawal and micro -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice. 14756803 2004
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Enhanced morphine withdrawal and micro -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice. 14756803 2004
CUI: C0242973
Disease: Ventricular Dysfunction
Ventricular Dysfunction 		0.300 Biomarker phenotype CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0751217
Disease: Hyperkinesia, Generalized
Hyperkinesia, Generalized 		0.300 Therapeutic phenotype CTD_human PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice. 15187444 2004
CUI: C3887506
Disease: Hyperkinesia
Hyperkinesia 		0.300 Therapeutic phenotype CTD_human PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice. 15187444 2004
CUI: C0001818
Disease: Agoraphobia
Agoraphobia 		0.020 GeneticVariation disease BEFREE Analyses carried out by broadening the panic disorder phenotype to include agoraphobia continued to support linkage to ADORA2A. 14666117 2004