ADORA2A, adenosine A2a receptor, 135

N. diseases: 213; N. variants: 10
Disease: Autistic Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.040 AlteredExpression disease BEFREE This study investigated the influence of adenosine A2A receptor activity on C-C and C-X-C chemokine receptors involved in autism in the BTBR mouse model. 28421534 2018
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.040 Biomarker disease BEFREE Adenosine A2A receptor (A2AR) signaling is involved in inflammation, brain injury, and lymphocyte infiltration into the CNS, but the role of A2AR in autism remains unknown. 28668513 2017
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.040 Biomarker disease BEFREE Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4<sup>+</sup> T cells from a BTBR T<sup>+</sup> Itpr3tf/J mouse model of autism. 28807491 2017
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.040 Biomarker disease BEFREE Adenosine A2A receptor modulates neuroimmune function through Th17/retinoid-related orphan receptor gamma t (RORγt) signaling in a BTBR T<sup>+</sup> Itpr3<sup>tf</sup>/J mouse model of autism. 28438638 2017