|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
Thus, D<sub>1</sub> receptors signalling towards CREB activation might participate in the onset and clinical responses to therapy in schizophrenia patients, by controlling ADAMTS2 expression and activity.
|
31740729 |
2019 |
|
Schizophrenia
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
It is not known which Shank binding partners are responsible for these defects.Here we show that the <i>C. elegans</i> SHN-1/Shank binds L-type calcium channels and that increased and decreased <i>shn-1</i> gene dosage alter L-channel current and activity-induced expression of a CRH-1/CREB transcriptional target (<i>gem-4</i> Copine), which parallels the effects of human Shank copy number variations (CNVs) on Autism spectrum disorders and schizophrenia.
|
28477407 |
2017 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
We used a convergent genomics approach, combining different lines of biological evidence, to identify genes involved in the cAMP/PKA/CREB functional pathway that could be novel candidates for BP and SZ: CREB1, CREM, GRIN2C, NPY2R, NF1, PPP3CB and PRKAR1A.
|
26899345 |
2016 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Nonetheless, we observed an association of a rare CREB1 haplotype CCGGC (Bonferroni corrected P = 1.74 × 10(-5)) with SCZ.
|
25043418 |
2014 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Nonetheless, we observed an association of a rare CREB1 haplotype CCGGC (Bonferroni corrected P = 1.74 × 10(-5)) with SCZ.
|
25043418 |
2014 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Two-hundred twenty one in-patients suffering from SKZ and 170 psychiatrically healthy controls were genotyped for 10 SNPs within CREB1, CREBBP and CREM.
|
22198373 |
2012 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia.
|
22198373 |
2012 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Overexpression of HERV-w env in human U251 glioma cells upregulated brain-derived neurotrophic factor (BDNF), an important schizophrenia-associated gene, neurotrophic tyrosine kinase receptor type 2 (NTRK2, also called TrkB), and dopamine receptor D3 and increased the phosphorylation of cyclic adenosine monophosphate response element-binding (CREB) protein.
|
20100784 |
2011 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia.
|
10570922 |
1999 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia.
|
10570922 |
1999 |