Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD.
|
28225778 |
2017 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
CREB1 gene polymorphisms combined with environmental risk factors increase susceptibility to major depressive disorder (MDD).
|
25755794 |
2015 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Alterations of brain anatomy in mouse model of MDD created by replacement of homologous mouse DNA sequence with an illness-associated 6-base human CREB1 promoter sequence.
|
24006268 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression.
|
23844928 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.
|
25059218 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression.
|
23844928 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This work also predicted that the genes with the greatest impact on model stability were those involved in the neurotrophin pathway, such as CREB, BDNF (which has been associated with major depressive disorder in a variety of studies) and TRkB, followed by genes and metabolites related to 5-HT synthesis.
|
24093582 |
2013 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
This work also predicted that the genes with the greatest impact on model stability were those involved in the neurotrophin pathway, such as CREB, BDNF (which has been associated with major depressive disorder in a variety of studies) and TRkB, followed by genes and metabolites related to 5-HT synthesis.
|
24093582 |
2013 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
IFN-α-treated patients with high depression/fatigue scores demonstrated up-regulation of genes bearing promoter motifs for transcription factors involved in myeloid differentiation, IFN-α and AP1 signaling, and reduced prevalence of motifs for CREB/ATF, which has been implicated in major depression.
|
22152193 |
2012 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder.
|
22386572 |
2012 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants.
|
20643483 |
2011 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder.
|
21598377 |
2011 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results continue to support sex-specific linkage of the CREB1 region to mood disorders among women from families with RE-MDD.
|
19517574 |
2010 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association study of CREB1 with Major Depressive Disorder and related phenotypes.
|
19194961 |
2009 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment-emergent suicidality in men with major depressive disorder, but its functional effects have not been studied.
|
18678793 |
2008 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder.
|
17300755 |
2007 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression.
|
17258370 |
2007 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To examine polymorphisms that span CREB1, which was previously associated with anger expression in men with major depressive disorder, for association with new or worsening suicidality.
|
17548750 |
2007 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression.
|
12457397 |
2002 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The blunted beta adrenoceptor-mediated PKA response in fibroblasts from patients with major depression is reflected in a significant reduction in the isoproterenol-stimulated phosphorylation of the nuclear transcription factor CREB.
|
11099740 |
2000 |