|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Some evidence suggests an association between genetic variants within the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB binding protein (CREBBP) and cAMP response element-modulator (CREM) and several psychiatric disorders.
|
22386572 |
2012 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We show that NR4A2 is a primary early transient gastrin induced gene in adenocarcinoma cell lines, and that NR4A2 expression is negatively regulated by inducible cAMP early repressor (ICER) and zinc finger protein 36, C3H1 type-like 1 (Zfp36l1), suggesting that these gastrin regulated proteins exert a negative feedback control of NR4A2 activated responses.
|
24086717 |
2013 |
|
Adult Clear Cell Sarcoma of Soft Parts
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
One CCSST case (6.3%) was found to have EWSR1 and CREM rearrangements, and 4 of 6 CCSLGT cases (66.7%) had EWSR1 rearrangement, of which 2 (33.3%) showed ATF1 rearrangement and the other 2 cases (33.3%) showed CREB1 rearrangement.
|
30219084 |
2018 |
|
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
CREM knock-out mice exhibit significantly less anxiety behavior than wild-type mice and the alternative CREM gene product "inducible cAMP early repressor" (ICER) plays a pivotal role in the hypothalamo-pituitary-adrenal (HPA) axis, which is disturbed in panic disorder.
|
12555239 |
2003 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
CREM knock-out mice exhibit significantly less anxiety behavior than wild-type mice and the alternative CREM gene product "inducible cAMP early repressor" (ICER) plays a pivotal role in the hypothalamo-pituitary-adrenal (HPA) axis, which is disturbed in panic disorder.
|
12555239 |
2003 |
|
Arteriovenous fistula
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The ICER of AVF (AVG) referral within 12 (3) months of forecasted HD initiation, compared to using only a CVC, is ∼$105k/QALY ($101k/QALY) at a population level (HD costs included).
|
28599902 |
2017 |
|
Atrial dilatation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-IbΔC-X in transgenic mice (TG) leads to spontaneous-onset AF preceded by atrial dilatation and conduction abnormalities.
|
28784605 |
2017 |
|
Atrial Fibrillation
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-IbΔC-X in transgenic mice (TG) leads to spontaneous-onset AF preceded by atrial dilatation and conduction abnormalities.
|
28784605 |
2017 |
|
Atrial Fibrillation
|
0.060 |
Biomarker
|
disease |
BEFREE |
In addition, control mice and mouse models of AF (cAMP-response element modulator (CREM)-IbΔC-X transgenic animals) or HF (cardiac dysfunction induced by transverse aortic constriction, TAC) were employed.
|
28526353 |
2017 |
|
Atrial Fibrillation
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Hemizygous mice with a cardiomyocyte-specific overexpression of the human cAMP response element modulator (CREM) isoform IbΔC-X spontaneously develop AF on grounds of an arrhythmogenic substrate consisting of alterations in structure, conduction, and calcium handling.
|
30026696 |
2018 |
|
Atrial Fibrillation
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
In cryptogenic strokes with subsequent AF detection, PELI1 and CREM showed overexpression (p = 0.017, p = 0.059, respectively), whereas in high-risk asymptomatic populations, all three genes showed potential to detect AF (p = 0.007, p = 0.007, p = 0.015).
|
31475302 |
2019 |
|
Atrial Fibrillation
|
0.060 |
Biomarker
|
disease |
BEFREE |
Finally, genetic inhibition of Nlrp3 prevented AF development in CREM transgenic mice, a well-characterized mouse model of spontaneous AF.
|
29802206 |
2018 |
|
Atrial Fibrillation
|
0.060 |
Biomarker
|
disease |
BEFREE |
Expression of cardiac K<sub>2P</sub> channels was quantified by real-time qPCR and immunoblot in mouse models of AF [cAMP-response element modulator (CREM)-IbΔC-X transgenic animals] or HF (cardiac dysfunction induced by transverse aortic constriction, TAC).
|
29881975 |
2018 |
|
Attention deficit hyperactivity disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CREM mutations and ADHD symptoms.
|
19201103 |
2009 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.
|
24667640 |
2014 |
|
Azoospermia, Nonobstructive
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicated that the polymorphisms of CREM gene were associated with NOA in the Chinese population and low CREM expression might be involved in the pathogenesis of spermatogenesis maturation arrest.
|
24943041 |
2014 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
From these, we validated and further characterized novel gene fusions involving ROS1 tyrosine kinase in angiosarcoma (CEP85L/ROS1), SLC1A2 glutamate transporter in colon cancer (APIP/SLC1A2), RAF1 kinase in pancreatic cancer (ATG7/RAF1) and anaplastic astrocytoma (BCL6/RAF1), EWSR1 in melanoma (EWSR1/CREM), CDK6 kinase in T-cell acute lymphoblastic leukemia (FAM133B/CDK6), and CLTC in breast cancer (CLTC/VMP1).
|
23637631 |
2013 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
These data suggest that ICER expression may function as an antioncogene to attenuate the expression of certain protooncogenes, thereby preventing transformation and oncogenesis due to continuous overexpression.
|
9544985 |
1998 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
By engineering clones of R545 melanoma cells stably transfected with ICER we were able to determine the prerequisite for Ras-induced tumorigenesis.
|
22488648 |
2013 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that deregulation of ICER expression may be related to carcinogenesis of the prostate gland.
|
11507053 |
2001 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Gene fusions of Ewing sarcoma breakpoint region 1 (EWSR1) with members of the cAMP response element-binding protein family (CREB) of transcription factors (CREB1, activating transcription factor 1 (ATF1), and cAMP response element modulator (CREM)) have been described in histopathologically diverse mesenchymal neoplasms such as AFH, hyalinising clear cell carcinomas of salivary glands, primary pulmonary myxoid sarcoma, and clear cell sarcoma.
|
31139520 |
2019 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
Finally, recent evidence suggests that cAMP-dependent transcription mechanisms may play a role during beta-adrenergic stimulation and cardiomyopathy with heart failure - by means of altered actions of cAMP response element binding protein, the cAMP response element modulator, or the activating transcription factor 1.
|
9826119 |
1998 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The ICER was most sensitive to uncertainty in the number of total avertable cardiovascular disease DALYs in the eligible population.
|
31537367 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that a direct protein-protein interaction between DREAM and the CREM repressor isoform, alphaCREM, prevents binding of DREAM to the DRE and suggests a mechanism for cyclic AMP-dependent derepression of the prodynorphin gene in human neuroblastoma cells.
|
11094064 |
2000 |