CREM, cAMP responsive element modulator, 1390

N. diseases: 100; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.010 Biomarker group BEFREE Gene fusions of Ewing sarcoma breakpoint region 1 (EWSR1) with members of the cAMP response element-binding protein family (CREB) of transcription factors (CREB1, activating transcription factor 1 (ATF1), and cAMP response element modulator (CREM)) have been described in histopathologically diverse mesenchymal neoplasms such as AFH, hyalinising clear cell carcinomas of salivary glands, primary pulmonary myxoid sarcoma, and clear cell sarcoma. 31139520 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.010 Biomarker group BEFREE The ICER was most sensitive to uncertainty in the number of total avertable cardiovascular disease DALYs in the eligible population. 31537367 2019
CUI: C0026847
Disease: Spinal Muscular Atrophy
Spinal Muscular Atrophy 		0.010 Biomarker disease BEFREE Spinal Muscular Atrophy Therapies: ICER Grounds the Price to Value Conversation in Facts. 31778615 2019
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.010 Biomarker group BEFREE Here we report the critical role of ventral striatal cAMP-response element modulator (CREM) in mediating impulsivity relevant to drug abuse vulnerability. 28439100 2018
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.010 Biomarker phenotype BEFREE Together, these results highlight that ventral striatal CREM mediates impulsivity related to substance abuse and suggest that CREM and its regulated network may be promising therapeutic targets. 28439100 2018
CUI: C0024530
Disease: Malaria
Malaria 		0.010 Biomarker disease BEFREE In a scenario of increasing pyrethroid resistance, the incremental expected cost per case of malaria averted is expected to increase compared with the base case (ICER: $192.12). 30014819 2018
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.010 GeneticVariation phenotype BEFREE Genetic studies in seven independent human populations illustrate that a CREM promoter variant at rs12765063 is associated with impulsivity, hyperactivity and addiction-related phenotypes. 28439100 2018
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		0.010 Biomarker disease BEFREE Together, these results highlight that ventral striatal CREM mediates impulsivity related to substance abuse and suggest that CREM and its regulated network may be promising therapeutic targets. 28439100 2018
CUI: C1298180
Disease: Single tumor
Single tumor 		0.010 GeneticVariation phenotype BEFREE An RREB1-MKL2 fusion product was identified in 19 tumors (90%), a single tumor (5%) had an EWSR1-CREM fusion product, and the remaining case lacked any known fusion gene by RNA Sequencing. 29912715 2018
CUI: C1332198
Disease: Adult Clear Cell Sarcoma of Soft Parts
Adult Clear Cell Sarcoma of Soft Parts 		0.010 GeneticVariation disease BEFREE One CCSST case (6.3%) was found to have EWSR1 and CREM rearrangements, and 4 of 6 CCSLGT cases (66.7%) had EWSR1 rearrangement, of which 2 (33.3%) showed ATF1 rearrangement and the other 2 cases (33.3%) showed CREB1 rearrangement. 30219084 2018
CUI: C1332964
Disease: Childhood Clear Cell Sarcoma of Soft Parts
Childhood Clear Cell Sarcoma of Soft Parts 		0.010 GeneticVariation disease BEFREE One CCSST case (6.3%) was found to have EWSR1 and CREM rearrangements, and 4 of 6 CCSLGT cases (66.7%) had EWSR1 rearrangement, of which 2 (33.3%) showed ATF1 rearrangement and the other 2 cases (33.3%) showed CREB1 rearrangement. 30219084 2018
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.010 AlteredExpression group BEFREE Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. 28439100 2018
CUI: C0003855
Disease: Arteriovenous fistula
Arteriovenous fistula 		0.010 Biomarker phenotype BEFREE The ICER of AVF (AVG) referral within 12 (3) months of forecasted HD initiation, compared to using only a CVC, is ∼$105k/QALY ($101k/QALY) at a population level (HD costs included). 28599902 2017
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.010 GeneticVariation disease BEFREE Model outcomes included lifetime risk of cervical cancer and incremental cost-effectiveness ratios (ICERs; international dollars/year of life saved).<b>Results:</b> In all three countries, HPV alone was more effective than HPV-VIA. 28710075 2017
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia 		0.010 Biomarker disease BEFREE Other outcomes at 6, 12 and 24 months - moderate and severe hypoglycaemia; insulin dose; body weight; proteinuria; diabetic ketoacidosis; quality of life (QoL); fear of hypoglycaemia; treatment satisfaction; emotional well-being; qualitative interviews with participants and staff (2 weeks), and participants (6 months); and ICERs in trial and modelled estimates of cost-effectiveness. 28440211 2017
CUI: C0025284
Disease: Meningeal Neoplasms
Meningeal Neoplasms 		0.010 Biomarker group BEFREE A second case with similar EWSR1-CREM fusion was identified by RT-PCR and FISH in a meningeal tumor. 28009602 2017
CUI: C0264734
Disease: Atrial dilatation
Atrial dilatation 		0.010 AlteredExpression disease BEFREE Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-IbΔC-X in transgenic mice (TG) leads to spontaneous-onset AF preceded by atrial dilatation and conduction abnormalities. 28784605 2017
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.010 GeneticVariation disease BEFREE Model outcomes included lifetime risk of cervical cancer and incremental cost-effectiveness ratios (ICERs; international dollars/year of life saved).<b>Results:</b> In all three countries, HPV alone was more effective than HPV-VIA. 28710075 2017
CUI: C0333875
Disease: High-Grade Squamous Intraepithelial Lesions
High-Grade Squamous Intraepithelial Lesions 		0.010 Biomarker phenotype BEFREE The ICER decreased as the age at HSIL management increased. 28950043 2017
CUI: C0341439
Disease: Chronic liver disease
Chronic liver disease 		0.010 AlteredExpression group BEFREE Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease. 27686093 2017
CUI: C1969372
Disease: Tubulointerstitial fibrosis
Tubulointerstitial fibrosis 		0.010 Biomarker phenotype BEFREE Tisp40, a transcription factor of the CREB/CREM family, is involved in cell proliferation, differentiation and other biological functions, but its role in renal tubulointerstitial fibrosis is unknown. 28618421 2017
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.010 GeneticVariation disease BEFREE Model outcomes included lifetime risk of cervical cancer and incremental cost-effectiveness ratios (ICERs; international dollars/year of life saved).<b>Results:</b> In all three countries, HPV alone was more effective than HPV-VIA. 28710075 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.010 Biomarker disease BEFREE The strategies of IHC + BRAF, germline testing and universal germline testing of colon cancer probands had ICERs of $144 117 and $996 878, respectively. 25794514 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 Biomarker disease BEFREE The strategies of IHC + BRAF, germline testing and universal germline testing of colon cancer probands had ICERs of $144 117 and $996 878, respectively. 25794514 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.010 Biomarker group BEFREE CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. 24667640 2014