|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although we did not replicate the specific interaction of abuse and the TAT-haplotype of the CRHR1 gene we confirmed the relevance of an interplay between variants within the CRHR1 gene and childhood adversities in the modulation of depression in adults.
|
20957648 |
2010 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Growth curve models were executed to determine whether CRHR1 moderated the link between Wave 1 family economic hardship and youths' development of depression.
|
26206446 |
2015 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS to predict depression, cognitive functions and hippocampal activity.
|
28461011 |
2017 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity.
|
24931706 |
2014 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking.
|
22957021 |
2012 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous research supports gene-environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5-HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life.
|
25422958 |
2014 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
RGD |
Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders.
|
20860876 |
2011 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data demonstrate that the CRHR1 TAT haplotype is associated with cognitive features of depression including difficulty with decision-making, higher rumination, and poorer learning and memory.
|
29317606 |
2018 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety.
|
28183242 |
2017 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 in CRHR1, predicting adult depression.
|
19736354 |
2009 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children.
|
25422957 |
2014 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating.
|
24166410 |
2014 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043).
|
26518448 |
2015 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Dysregulation in the stress response of the hypothalamic-pituitary-adrenocortical (HPA) axis, involving the corticotrophin-releasing hormone (CRH) and its main receptor (CRHR1), is associated with depression, frequent among suicidal males.
|
17376150 |
2008 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk.
|
21998007 |
2011 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study partially replicates recent findings of a CRHR1 by childhood adversity interaction with regard to adult depression highlighting the subjective characteristics of the environmental pathogen that is operative in this interaction.
|
22748421 |
2013 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because CRHR1 affects both depression and anxiety.
|
15365580 |
2004 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier.
|
31737064 |
2019 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.
|
24741566 |
2014 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis.
|
24933348 |
2015 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress.
|
24867333 |
2014 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict hypothalamic-pituitary-adrenal (HPA) axis reactivity, which has been linked to both depression and early life stress.
|
19596121 |
2009 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Similarly, we recently discovered that genetic variation in components of the stress-related hypothalamic pituitary adrenocortical axis, T-box 19 and corticotropin releasing hormone receptor 1, showed association and linkage to high anger/hostility in and male depression the suicidal offspring, respectively.
|
17585962 |
2007 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The recent characterisation of several selective small-molecule CRHR1 antagonists offers new possibilities for the treatment of anxiety and depression.
|
15310462 |
2004 |