Disease: Alcohol Use Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.050 Biomarker disease BEFREE A prototypical example is that of corticotropin releasing factor type 1 receptor (CRF1R) antagonists that showed significant effectiveness in animal models of AUD but were largely ineffective in humans. 31112713 2019
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.050 Biomarker disease BEFREE Mice with a history of episodic social defeat stress were selectively sensitive to the effects of CRF-R1 antagonism, suggesting that CRF-R1 may be a potential target for treating alcohol use disorders in individuals who escalate their drinking after exposure to repeated bouts of psychosocial stress. 29696309 2018
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.050 Biomarker disease BEFREE The Corticotropin Releasing Factor Receptor 1 in Alcohol Use Disorder: Still a Valid Drug Target? 28940382 2017
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.050 Biomarker disease BEFREE Association of CRHR1 and CRHBP genotypes with the following: (1) AUD; (2) a newly developed alcoholism severity score comprising 5 AUD-relevant variables; and (3) quantitative CRHR1 and CRHBP messenger RNA expression. 21810631 2011
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.050 Biomarker disease BEFREE Our findings support results from animal models, suggesting an importance of CRHR1 in integrating gene-environment effects in alcohol use disorders. 16550213 2006