|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes.
|
1476792 |
1992 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Human tumor tropic mesenchymal stem cells (MSCs) isolated from various tissues and MSCs engineered to express the yeast cytosine deaminase::uracil phosphoribosyl transferase suicide fusion gene (yCD::UPRT-MSCs) released exosomes in conditional medium (CM).
|
30098225 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The results clearly indicate that AlPcS2a-mediated PCI can be used to enhance transfection of a tumor suicide gene such as CD, in malignant glioma cells and cells transfected with both the CD and UPRT genes had a pronounced bystander effect.
|
24610460 |
2014 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
CDy::UPRT-MSCs in direct cocultures with breast cancer cells MDA-MB-231 increased tumor cell killing induced by low concentrations of 5FU.
|
22265744 |
2012 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Subcutaneous injection of AdMDR1-CD::UPP into the xenografts of mice bearing tumors of A2780/Taxol cells could significantly suppress the tumor growth and prolong survival as compared with the group of A2780 cells.
|
17471022 |
2007 |
|
Malignant neoplasm of pancreas
|
0.040 |
Biomarker
|
disease |
BEFREE |
Suicide gene therapy with FCY1 gene, encoding cytosine deaminase (CD), together with FUR1, encoding uracil phosphoribosyltransferase (UPRT), has been proposed for pancreatic cancer therapy in vivo.
|
17895842 |
2007 |
|
Malignant neoplasm of pancreas
|
0.040 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to evaluate cytotoxicity in vitro and therapeutic efficacy in vivo of the combination of Ad-CD:UPRT and TRA-8 against human pancreatic cancer and glioma cell lines.
|
16082379 |
2006 |
|
Malignant neoplasm of pancreas
|
0.040 |
Biomarker
|
disease |
BEFREE |
Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors.
|
12353234 |
2002 |
|
Malignant neoplasm of pancreas
|
0.040 |
Biomarker
|
disease |
BEFREE |
The present study demonstrates that adenovirus-mediated transduction of E. coli UPRT gene results in marked sensitization of colon, gastric, liver, and pancreas cancer cell lines to low concentration of 5-FU in vitro.
|
9581837 |
1998 |
|
Pancreatic carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Suicide gene therapy with FCY1 gene, encoding cytosine deaminase (CD), together with FUR1, encoding uracil phosphoribosyltransferase (UPRT), has been proposed for pancreatic cancer therapy in vivo.
|
17895842 |
2007 |
|
Pancreatic carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to evaluate cytotoxicity in vitro and therapeutic efficacy in vivo of the combination of Ad-CD:UPRT and TRA-8 against human pancreatic cancer and glioma cell lines.
|
16082379 |
2006 |
|
Pancreatic carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The present study demonstrates that adenovirus-mediated transduction of E. coli UPRT gene results in marked sensitization of colon, gastric, liver, and pancreas cancer cell lines to low concentration of 5-FU in vitro.
|
9581837 |
1998 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results suggested that adenovirus-mediated UPRT gene transduction combined with 5-FU administration and radiation may be an effective new chemo-radio-gene therapy for colorectal cancer.
|
12820392 |
2003 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results suggested that adenovirus-mediated UPRT gene transduction combined with 5-FU administration and radiation may be an effective new chemo-radio-gene therapy for colorectal cancer.
|
12820392 |
2003 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that adenoviral-mediated transfer of the E. coli UPRT gene into colon cancer cells can achieve biochemical modulation of 5-FU and this provides a new approach in the treatment of colorectal cancer.
|
11094317 |
2000 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that adenoviral-mediated transfer of the E. coli UPRT gene into colon cancer cells can achieve biochemical modulation of 5-FU and this provides a new approach in the treatment of colorectal cancer.
|
11094317 |
2000 |
|
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Autophagy increases in placenta-related obstetrical diseases such as preeclampsia and intrauterine growth retardation but the regulation of autophagy by ubiquitin proteasome pathway (UPP) proteins, p97/Valosin containing protein (VCP) and ubiquitin (Ub) have not been previuosly studied in preeclampsia.
|
29941173 |
2018 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A M. tuberculosis knockout strain for upp gene was generated by allelic replacement.
|
28130366 |
2017 |
|
Cystitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We describe two patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene.
|
26525799 |
2016 |
|
Infective cystitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We describe two patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene.
|
26525799 |
2016 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
|
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
It has been indicated that the pathogenic effect of UPP on DR was involved in the increase of ROS generation and NF-κB expression, which associated with the ROS/PARP and NF-κB inflammatory factor pathways.
|
26391545 |
2015 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Systemic administration of CD::UPRT-MSC and HSVtk-MSC in combination with 5-FC and GCV inhibited growth of MDA-MB-231 induced lung metastases.
|
25884597 |
2015 |
|
Epiretinal Membrane
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical study showed the overexpression of UPP and detachment of epiretinal membranes in proliferative DR (PDR) patients.
|
26391545 |
2015 |