CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE The cutoff values of D-dimer and CRP to identify stroke due to Trousseau's syndrome was 2.68 µg/mL fibrinogen equivalent units and .29 mg/dL, respectively. 31810721 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE In analyses controlled for age, sex, race, diabetes duration, body mass index, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, kidney function and a history of smoking, a history of stroke was significantly inversely associated with serum perfluorohexane sulphate (odds ratio = 0.75, 0.64-0.88) and perfluoroctane sulfonate (odds ratio = 0.81, 0.70-0.90), but not perfluorooctanoic acid (odds ratio = 1.04, 0.94-1.15) or perfluorononaoic acid (odds ratio = 0.89, 0.70-1.14) among those with diabetes. 31841043 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE In a recent US-based nationwide registry study, about 10% of all hospitalized ischemic stroke patients had comorbid cancer, with a slight rise in this rate over the last decade.<sup>2</sup> Stroke patients diagnosed with occult cancer are usually older with men being at a higher risk of having comorbid cancer.<sup>3,4</sup> In addition, probability of cancer diagnosis after stroke is associated with smoking, elevated D-dimer, elevated C-reactive protein (CRP), and anemia on admission. 31701522 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Relationship between high-sensitivity C-reactive protein and early neurological deterioration in stroke patients with and without atrial fibrillation. 31699451 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Elevated C-reactive protein increases diagnostic accuracy of algorithm-defined stroke-associated pneumonia in afebrile patients. 30196790 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE CRP has a significant direct, yet weak, correlation to the severity of stroke. 30991382 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Multiple regression analysis with the total Japanese version of the Montreal Cognitive Assessment score as the dependent variable showed that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and sex were related to the Japanese version of the Montreal Cognitive Assessment total score at the age of 70 years, and that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and stroke were related at the age of 80 years. 31461209 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Patients with first-in-life stroke were analysed according to: plasma concentration of the following markers on the first day of stroke: interleukin 2 (IL-2) and interleuki 6 (IL-6), S100B, tumor necrosis factor-α (TNF-α), progranulin (GRN), neuron specific enolase (NSE), urokinase-type plasminogen activator (uPA), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), leucocyte and thrombocyte counts; their neurological status on the first day of stroke (NIHSS) and their functional status at 30 days following stroke (mRS). 31356182 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group BEFREE The control of both LDL cholesterol and CRP levels appears to be effective for preventing recurrent stroke and TIA in patients with non-cardiogenic ischemic stroke. 30318492 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE We calculated hazard ratios and 95% CIs of ischemic stroke by CRP category (<1, 1-3, 3-10, and ≥10 mg/L) adjusted for age, sex and stroke risk factors. 31520899 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE High CRP value was independently associated with 3-month poor outcome after stroke in patients without infection. 31738143 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE The adjusted relationship between the 3-year composite rate of death, MI, or stroke and baseline CRP modeled as a continuous log-transformed variable demonstrated steadily increasing event rates with greater CRP levels (adjusted hazard ratio, 1.26, 95% CI 1.10-1.44, P = .0008). 30738244 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE ROC curve analysis shows the area under curve of the statistical model was 0.823, the analysis of diagnostic threshold for prognostic factors indicated that age, diffusion-weighted imaging lesion volume, glucose on admission, National Institutes of Health Stroke Scale score on admission and hypersensitive C-reactive protein were valuable predictive factors for the outcome of EVT (P<0.05). 31641377 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group BEFREE Body mass index (BMI), waist circumference values, the average values of systolic (SBP) and diastolic (DBP) blood pressures and heart rate, total serum cholesterol levels, serum HDL (high-density lipoprotein) cholesterol levels, serum LDL (low-density lipoprotein) cholesterol levels, serum triglycerides levels, serum lipoprotein A levels, serum CRP (C-reactive protein) levels, plasma homocysteine levels, serum uric acid levels, individual and relative risks of having a heart attack or stroke over the next ten years were compared between groups (50 GH, 102 PE, 34 FGR and 90 normal pregnancies) and correlated with the severity of the disease with regard to clinical signs (25 PE without severe features, 77 PE with severe features), and delivery date (36 early PE, 66 late PE). 31010048 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients. 30729371 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group BEFREE However, serum folate and vitamin B<sub>12</sub> levels were not associated with the risk of stroke, coronary artery disease, or myocardial infarction or the development of peripheral arterial disease after adjustment for age, sex, smoking status, alcohol consumption, physical activity, body mass index, serum creatinine, and high-sensitivity C-reactive protein levels and a history of diabetes, hypertension, or dyslipidemia. 30824395 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE In both sexes, there was no difference between patients with normal or high CRP regarding overall macroangiopathy (42% vs. 45% [men]; 27% vs. 28% [women]), coronary and peripheral artery disease, or stroke. 31477553 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE At the end of the 5-year follow- up, compared with subjects without MS, hazard ratios and 95% confidence intervals for the different risks in subjects with MS were 1.86 (1.02-3.29) for myocardial infarction (MI), 1.39 (1.01-2.05) for stroke, 1.52 (1.02- 2.37) for CVD death, and 1.13 (0.62-2.58) for total death, after adjusting for age, gender, smoking, drinking, physical activity, uric acid, high-sensitivity C-reactive protein, dietary factors and carotid atherosclerosis status. 31826385 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 AlteredExpression group BEFREE This study examined the association between physical activity, SB, and CRP in stroke. 30160575 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE The addition of CRP with eosinophil and/or neutrophil count significantly improved a base model for the prediction of mortality which included age, gender, race/ethnicity, body mass index, smoking, poverty income ratio, asthma, diabetes, hypertension and history of stroke or myocardial infarction. 29227024 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE In the multivariable analysis, higher vWF concentrations (middle tertile hazard ratio [HR] 4.59, 95% confidence interval [CI] 1.55-13.50 [P=0.006]; upper tertile HR 4.10, 95% CI 1.43-11.75 [P=0.009]), age≥75years (HR 5.02, 95% CI 1.53-16.49; P=0.008), heart failure (HR 2.05, 1.01-4.19; P=0.048), C-reactive protein, log<sub>2</sub> per unit increase (HR 1.29, 95% CI 1.04-1.61; P=0.021), no warfarin at discharge (HR 4.96, 95% CI 2.02-12.20; P<0.0001) and no aspirin at discharge (HR 4.41, 95% CI 1.71-11.97; P=0.002) were independently associated with an increased risk of stroke and all-cause death, whereas female sex was a protective factor (HR 0.35, 0.16-0.78; P=0.01). 29685722 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE The AHEI-2010 was inversely associated with stroke (HR 0.66; 95% CI 0.42, 0.88) incidence, aortic pulse wave velocity, and C-reactive protein. 28293738 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Using CRP and T3 as prognostic factors resulted in a probability of 53.5% to predict a poor functional outcome and of 80.42% to predict a poor cognitive outcome in stroke patients at discharge. 30056003 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 Biomarker group BEFREE Potential indirect associations of high-sensitivity C-reactive protein and the Framingham Stroke Risk Profile also were examined. 28437380 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.100 GeneticVariation group BEFREE This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. 29556980 2018