|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.
|
21278247 |
2011 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.
|
21278247 |
2011 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity.
|
17568789 |
2007 |
|
Dwarfism
|
0.300 |
Biomarker
|
disease |
CTD_human |
Most Crtl1(tm1Nid/tm1Nid) mice died shortly after birth due to respiratory failure, but some survived and developed progressive dwarfism and lordosis of the cervical spine.
|
9988279 |
1999 |
|
Limb Deformities, Congenital
|
0.300 |
Biomarker
|
group |
CTD_human |
Mice lacking link protein develop dwarfism and craniofacial abnormalities.
|
9988279 |
1999 |
|
Craniofacial Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Mice lacking link protein develop dwarfism and craniofacial abnormalities.
|
9988279 |
1999 |
|
Spondyloepiphyseal dysplasia, congenita
|
0.200 |
Biomarker
|
disease |
MGD |
Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency.
|
12732630 |
2003 |
|
Spondyloepiphyseal dysplasia, congenita
|
0.200 |
Biomarker
|
disease |
MGD |
Mice lacking link protein develop dwarfism and craniofacial abnormalities.
|
9988279 |
1999 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis.
|
30279172 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Reconstituting HAPLN1 inhibited metastasis in an aged microenvironment, in 3-D skin reconstruction models, and <i>in vivo</i>.
|
30279173 |
2019 |
|
Metastatic Malignant Neoplasm in the Viscera
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, reconstitution of HAPLN1 in aged mice increased the number of LN metastases, but reduced visceral metastases.
|
30279172 |
2019 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose that HAPLN1 is a novel pathogenic factor in MM that induces an atypical NF-κB activation and thereby promotes bortezomib resistance in MM cells.
|
29279332 |
2018 |
|
Spinal Muscular Atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results describe the association between PNN elements, especially HAPLN1, and SMA pathophysiology for the first time.
|
30106667 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of the present study indicated that <i>HAPLN1, hsa-miR-204</i> and <i>hsa-miR-218</i> may be involved in the pathogenesis of ccRCC.
|
29805586 |
2018 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicated that CRT1, an ent‑kaurane diterpenoid, may be a potential inhibitor of ovarian cancer by the activating ERK1/2/p90 ribosomal S6 kinase signaling pathway.
|
30106144 |
2018 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicated that CRT1, an ent‑kaurane diterpenoid, may be a potential inhibitor of ovarian cancer by the activating ERK1/2/p90 ribosomal S6 kinase signaling pathway.
|
30106144 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Additionally, CRT1 inhibited cell migration and invasion via ERK1/2 activation in SKOV3 cells.
|
30106144 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicated that CRT1, an ent‑kaurane diterpenoid, may be a potential inhibitor of ovarian cancer by the activating ERK1/2/p90 ribosomal S6 kinase signaling pathway.
|
30106144 |
2018 |
|
Kashin-Beck Disease
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
MS and IHC confirmed the hypermethylation status and decreased protein expression of HAPLN1 gene in KBD cartilage.
|
28818737 |
2017 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, HAPLN1 reflects a signaling network leading to stemness, mesenchymal commitment and HCC progression.
|
27191501 |
2016 |
|
Ankylosing spondylitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese.
|
23308121 |
2013 |
|
External exotoses
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women.
|
20953637 |
2011 |
|
Intervertebral Disc Degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women.
|
20953637 |
2011 |
|
Degeneration of spine
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Consistent with the involvement of the HAPLN1 gene in cartilage metabolism, a variation in a specific HAPLN1 gene locus may be associated with spinal degeneration.
|
20953637 |
2011 |