CRY2, cryptochrome circadian regulator 2, 1408

N. diseases: 76; N. variants: 9
Disease: Hyperaldosteronism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020428
Disease: Hyperaldosteronism
Hyperaldosteronism 		0.010 Biomarker disease BEFREE Mice lacking the core-clock components, cryptochrome-1 (CRY1) and cryptochrome-2 (CRY2) display a phenotype of hyperaldosteronism, due to the upregulation of type VI 3β-hydroxyl-steroid dehydrogenase (<i>Hsd3b6</i>), the murine counterpart to the human type I 3β-hydroxyl-steroid dehydrogenase (<i>HSD3B1</i>) gene. 29874863 2018